McLennan M K
Department of Radiology, Toronto Hospital, Canada.
Skeletal Radiol. 1991;20(2):141-4. doi: 10.1007/BF00193830.
Malignant epithelial thymomas are slowly growing anterior mediastinal tumors. Local invasion and intrathoracic spread are not uncommon. Evidence of extrathoracic metastases are found in up to 15% of patients, most commonly in the liver, kidney, and bone. Almost all reports of thymoma metastases to bone have described purely lytic lesions. Once extrathoracic metastatic deposits are discovered, the mean extent of survival is 18 months. A case of a malignant epithelial thymoma in a young woman with diffuse sclerotic metastases to bone is reported. This case is remarkable not only for the presence and extent of the osteoblastic metastases but also for the fact that this woman lived for 6 years following the discovery of the extrathoracic bone involvement.
恶性上皮性胸腺瘤是生长缓慢的前纵隔肿瘤。局部侵犯和胸腔内播散并不少见。高达15%的患者有胸外转移证据，最常见于肝脏、肾脏和骨骼。几乎所有胸腺瘤骨转移的报告都描述为单纯溶骨性病变。一旦发现胸外转移灶，平均生存时间为18个月。本文报告一例年轻女性恶性上皮性胸腺瘤，伴有弥漫性骨硬化转移。该病例不仅因其成骨性转移的存在和范围引人注目，而且该女性在发现胸外骨受累后存活了6年这一事实也很显著。
