Cusano Antonio, Wellington Ian J, Forouhar Faripour A, Mallozzi Scott S
Department of Orthopedic Surgery, University of Connecticut, Farmington, Connecticut, United States.
Department of Pathology and Laboratory Medicine, University of Connecticut, Farmington, Connecticut, United States.
J Orthop Case Rep. 2023 Apr;13(4):66-70. doi: 10.13107/jocr.2023.v13.i04.3620.
While metastases of malignant thymomas have been shown, type A thymomas are often treated as benign. Type A thymomas often have excellent response to treatment, low recurrence rate, and a small malignant potential. To date, there have been no reports of type A thymomas with spinal metastases.
A 66-year-old female with a type A thymoma metastatic to the T7 and T8 vertebral bodies and brain, with associated pathologic burst fracture, collapse of T7, and significant focal kyphosis . The patient underwent successful T7-T8 posterior corpectomy and T4-T11 posterior spinal fusion. At 2 years of follow-up, she was ambulating without assistive devices and completed spinal radiation and initial chemotherapy.
Metastatic type A thymoma is a rare phenomenon. While traditionally thought to have low recurrence rates and overall excellent survival rates, our case suggests that the biologic malignant potential of a type A thymoma may not be fully understood.
虽然恶性胸腺瘤的转移已得到证实，但 A 型胸腺瘤通常被当作良性肿瘤治疗。A型胸腺瘤对治疗常常有良好反应，复发率低，恶性潜能小。迄今为止，尚无 A 型胸腺瘤发生脊柱转移的报道。
一名 66 岁女性，其 A 型胸腺瘤转移至 T7 和 T8 椎体及脑部，伴有病理性爆裂骨折、T7 椎体塌陷和明显的局部后凸畸形。该患者成功接受了 T7 - T8 后路椎体次全切除术及 T4 - T11 后路脊柱融合术。在随访 2 年时，她无需辅助装置即可行走，并完成了脊柱放疗和初始化疗。
转移性 A 型胸腺瘤是一种罕见现象。虽然传统上认为其复发率低且总体生存率良好，但我们的病例表明，A型胸腺瘤的生物学恶性潜能可能尚未被完全了解。
