Babincova Melania, Babinec Peter
Department of Nuclear Physics and Biophysics, Faculty of Mathematics, Physics, and Informatics, Comenius University, Mlynska dolina F1, Bratislava, Slovakia.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009 Dec;153(4):243-50. doi: 10.5507/bp.2009.042.
Nanomaterials are at the leading edge of the rapidly developing field of nanotechnology. Magnetic nanoparticles for cancer therapy and diagnosis have been developed on the basis of their unique physico-chemical properties not present in other materials. Their versatility is widely exploited in such diverse techniques as cell and macromolecule separation and purification, immunoassays, targeted drug delivery, controlled material release, electromagnetic hyperthermia, gene therapy, or magnetic resonance imaging. In this review we concentrate on the physical principles of magnetic drug targeting and biomedical applications of this technique.
We examined several databases, PubMed, ISI Web of Knowledge, and Scopus, for the period 1985-2009, with specific attention to studies that used targeting of magnetic nanoparticles especially in the therapy and diagnostics of tumors. We have also presented several of our own results on theoretical simulations of magnetic particle motion in external magnetic field.
We found growing number of published papers in this field of nanomedicine, showing the almost unlimited potential of magnetic nanoparticles in the field of experimental and clinical oncology.
纳米材料处于快速发展的纳米技术领域的前沿。用于癌症治疗和诊断的磁性纳米颗粒是基于其独特的物理化学性质开发的，这些性质在其他材料中并不存在。它们的多功能性在细胞和大分子分离与纯化、免疫测定、靶向药物递送、可控材料释放、电磁热疗、基因治疗或磁共振成像等多种技术中得到广泛应用。在本综述中，我们专注于磁性药物靶向的物理原理及其在生物医学中的应用。
我们检索了1985年至2009年期间的几个数据库，即PubMed、ISI Web of Knowledge和Scopus，特别关注使用磁性纳米颗粒靶向的研究，尤其是在肿瘤治疗和诊断方面。我们还展示了我们自己关于外磁场中磁性颗粒运动理论模拟的一些结果。
我们发现纳米医学这一领域发表的论文数量不断增加，显示出磁性纳米颗粒在实验和临床肿瘤学领域几乎具有无限潜力。
