Girianelli Vania Reis, Thuler Luiz Claudio Santos, e Silva Gulnar Azevedo
Departamento de Epidemiologia, Instituto de Medicina Social, Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Rev Bras Ginecol Obstet. 2010 Jan;32(1):39-46. doi: 10.1590/s0100-72032010000100007.
to evaluate the prevalence of HPV infection and associated factors among women living in the 'Baixada Fluminense', state of Rio de Janeiro, Brazil.
a cross-sectional study conducted on a sample of 2,056 women aged 25-59 years covered by the Family Health Program in the municipalities of Duque de Caxias and Nova Iguaçu, state of Rio de Janeiro, southeastern Brazil. All women were submitted to the Papanicolaou and HPV detection tests in a single session by second-generation hybrid capture from December 2001 to July 2002. The prevalence of HPV was stratified by age, place of residence, schooling, smoking habit, and sexual and reproductive history. The prevalence rates associated with the studied variables were calculated by Multivariate Poisson regression.
the prevalence of HPV was 12.3% and 5.0% for high-risk and low-risk HPV types, respectively. A reduction in high-risk HPV prevalence was observed with aging, with an increase in the 55-59 year age range. After adjusting for age, schooling, smoking, early sexual initiation and parity, high-risk HPV infection was associated with not living with a partner (1.4; 95%CI=1.1-1.8) and having more than one sexual partner (an increase of 1.4%; 95%CI=1.1-1.6, for each lifetime sexual partner).
the prevalence of HPV was lower than that reported in other Brazilians studies, most likely because our sample was population-based. HPV infection was associated only with factors related to sexual behavior, but the potential association between HPV infection and smoking still needs to be better understood. Further studies are needed to explore these issues, as well as postmenopausal increased infection rates, and to identify the most prevalent HPV types in the Brazilian population.
评估巴西里约热内卢州“弗卢米嫩塞低地”地区女性人乳头瘤病毒（HPV）感染率及其相关因素。
在巴西东南部里约热内卢州杜克卡西亚斯市和新伊瓜苏市，对2056名年龄在25至59岁、参加家庭健康计划的女性进行横断面研究。2001年12月至2002年7月期间，所有女性均在同一次检查中接受巴氏涂片检查和采用第二代杂交捕获技术检测HPV。HPV感染率按年龄、居住地点、受教育程度、吸烟习惯以及性和生殖史进行分层。通过多变量泊松回归计算与研究变量相关的感染率。
高危型和低危型HPV的感染率分别为12.3%和5.0%。随着年龄增长，高危型HPV感染率降低，在55至59岁年龄组有所上升。在对年龄、受教育程度、吸烟、初次性行为过早和生育次数进行校正后，高危型HPV感染与未与伴侣同住（1.4；95%置信区间=1.1 - 1.8）以及有多个性伴侣（每增加一个性伴侣，感染率增加1.4%；95%置信区间=1.1 - 1.6）有关。
HPV感染率低于巴西其他研究报告的水平，很可能是因为我们的样本是以人群为基础的。HPV感染仅与性行为相关因素有关，但HPV感染与吸烟之间的潜在关联仍需进一步深入了解。需要进一步开展研究来探讨这些问题以及绝经后感染率增加的情况，并确定巴西人群中最常见的HPV类型。
