Bucur Barbara, Madden David J
Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, USA.
Exp Aging Res. 2010 Apr;36(2):153-68. doi: 10.1080/03610731003613482.
Previous research has established that the effects of chronically increased blood pressure (BP) on cognition interact with adult age, but the relevant cognitive processes are not well defined. In this cross-sectional study, using a sample matched for age, years of education, and sex, 134 individuals with either normal BP (n = 71) or chronically high BP (n = 63) were categorized into younger (19-39 years), middle-aged (41-58 years), and older (60-79 years) groups. Using a between-subjects analysis of variance (ANOVA), covarying for race and years of education, composite measures of executive function and perceptual speed both exhibited age-related decline. The executive function measure, however, was associated with a differential decline in high BP older adults. This result held even when the executive function scores were covaried for speed, demonstrating an independent, age-related effect of higher BP on executive function.
先前的研究已经证实，长期血压升高（BP）对认知的影响与成年年龄相互作用，但相关的认知过程尚未明确界定。在这项横断面研究中，选取了年龄、受教育年限和性别相匹配的样本，将134名血压正常（n = 71）或长期血压高（n = 63）的个体分为年轻组（19 - 39岁）、中年组（41 - 58岁）和老年组（60 - 79岁）。采用组间方差分析（ANOVA），对种族和受教育年限进行协变量调整，执行功能和感知速度的综合测量均显示出与年龄相关的下降。然而，执行功能测量与高血压老年个体的差异性下降有关。即使在执行功能得分对速度进行协变量调整时，这一结果仍然成立，表明较高的血压对执行功能具有独立的、与年龄相关的影响。
