老年人群中动脉高血压与认知功能的关系。系统评价与荟萃分析。
Relationship between Arterial Hypertension with Cognitive Performance in Elderly. Systematic Review and Meta-Analysis.
作者信息
Sánchez-Nieto José Miguel, Rivera-Sánchez Uriel Dagoberto, Mendoza-Núñez Víctor Manuel
机构信息
Research Unit on Gerontology, FES Zaragoza, National Autonomou, University of Mexico, Mexico City 04510, Mexico.
出版信息
Brain Sci. 2021 Oct 29;11(11):1445. doi: 10.3390/brainsci11111445.
BACKGROUND
Previous systematic reviews report that arterial hypertension (AHT) is associated with lower performance in cognition in the elderly. However, some studies show that with higher blood pressure, a better cognitive performance is obtained.
OBJECTIVE
The aim of this study was to determine the relationship between AHT with cognitive performance in the elderly.
METHODS
the review involved a search on PubMed, Scopus and PsycINFO databases from January 1990 to March, 2020 to identify the relationship among AHT and cognitive performance in older people.
RESULTS
1170 articles were identified, 136 complete papers were reviewed, a qualitative analysis of 26 studies and a quantitative analysis of eight studies were carried out. It was found that people with AHT have a lower performance in processing speed SMD = 0.40 (95% CI: 0.25, 0.54), working memory SMD = 0.28 (95% CI: 0.15, 0.41) in short-term memory and learning SMD = -0.27 (95% CI: -0.37, -0.17) and delayed recall SMD = -0.20 (95% CI: -0.35, -0.05). Only one study found that higher blood pressure was associated with better memory performance.
CONCLUSION
Our results suggest that high blood pressure primarily affects processing speed, working memory, short-term memory and learning and delayed recall.
背景
以往的系统评价报告称，老年人群中动脉高血压（AHT）与认知能力下降有关。然而，一些研究表明，血压升高时认知表现更好。
目的
本研究旨在确定老年人群中AHT与认知表现之间的关系。
方法
本综述检索了1990年1月至2020年3月期间的PubMed、Scopus和PsycINFO数据库，以确定老年人中AHT与认知表现之间的关系。
结果
共识别出1170篇文章，对136篇完整论文进行了综述，对26项研究进行了定性分析，对8项研究进行了定量分析。结果发现，患有AHT的人群在处理速度方面表现较差，标准化均数差（SMD）=0.40（95%置信区间：0.25，0.54）；工作记忆方面，SMD=0.28（95%置信区间：0.15，0.41）；短期记忆和学习方面，SMD=-0.27（95%置信区间：-0.37，-0.17）；延迟回忆方面，SMD=-0.20（95%置信区间：-0.35，-0.05）。只有一项研究发现血压升高与更好的记忆表现相关。
结论
我们的结果表明，高血压主要影响处理速度、工作记忆、短期记忆和学习以及延迟回忆。
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