甘氨酸丙酰-L-肉碱可调节人体的脂质过氧化和一氧化氮。

Glycine propionyl-L-carnitine modulates lipid peroxidation and nitric oxide in human subjects.

机构信息

Department of Health and Sport Sciences, University of Memphis, Memphis, TN 38152, USA.

出版信息

Int J Vitam Nutr Res. 2009 May;79(3):131-41. doi: 10.1024/0300-9831.79.3.131.

DOI:10.1024/0300-9831.79.3.131

PMID:20209464

Abstract

OBJECTIVE

To determine the efficacy of glycine propionyl-L-carnitine (GPLC) to decrease lipid peroxidation, elevate nitric oxide, and improve blood lipid profiles in human subjects.

METHODS

Thirty untrained, normolipidemic subjects performed eight weeks of supervised aerobic exercise while supplementing GPLC at one of two doses (1 or 3 grams daily of PLC + glycine) or placebo, following random assignment in a double-blind manner. Fasting blood samples were analyzed at rest for malondialdehyde, nitric oxide, and lipids before and after the intervention.

RESULTS

Malondialdehyde was decreased (p<0.05) from pre- to post-intervention with 1 g GPLC (1.08+/-0.24 vs. 0.69+/-0.25 micromol.L (-1)) and 3 g GPLC (0.94+/-0.18 vs. 0.66+/-0.17 micromol.L (-1)), but did not change statistically (p>0.05) with placebo (1.12+/-0.21 vs. 1.03+/-0.23 micromol.L (-1)). Nitric oxide was increased (p<0.05) from pre- to post-intervention with 3 g GPLC (21.34+/-2.27 vs. 29.46+/-3.61 micromol.L (-1)), but did not change statistically (p>0.05) with 1 g GPLC (23.22+/-4.13 vs. 26.24+/-4.32 micromol.L (-1)) or placebo (24.31+/-3.90 vs. 26.14+/-4.11 micromol.L (-1)). No main effects or interaction effects were noted for blood lipids (p>0.05).

CONCLUSION

GPLC supplementation combined with eight weeks of aerobic exercise decreases lipid peroxidation and elevates nitric oxide, but does not further improve blood lipid profiles in normolipidemic subjects.

摘要

目的

确定甘氨酸丙酰-L-肉碱（GPLC）降低脂质过氧化、提高一氧化氮和改善人体血脂谱的功效。

方法

30 名未经训练的正常血脂个体在接受监督的有氧运动的同时，以两种剂量（每天 1 或 3 克 PLC+甘氨酸）或安慰剂进行补充，随机分配后进行双盲。在干预前后，空腹血样在休息时进行分析，用于检测丙二醛、一氧化氮和血脂。

结果

1 g GPLC（1.08+/-0.24 对 0.69+/-0.25 μmol/L(-1)) 和 3 g GPLC（0.94+/-0.18 对 0.66+/-0.17 μmol/L(-1)) 使丙二醛从干预前到干预后降低（p<0.05），但安慰剂（1.12+/-0.21 对 1.03+/-0.23 μmol/L(-1)) 没有统计学上的变化（p>0.05）。一氧化氮从干预前到干预后增加（p<0.05），3 g GPLC（21.34+/-2.27 对 29.46+/-3.61 μmol/L(-1))，但 1 g GPLC（23.22+/-4.13 对 26.24+/-4.32 μmol/L(-1)) 或安慰剂（24.31+/-3.90 对 26.14+/-4.11 μmol/L(-1)) 没有统计学上的变化。血脂没有主要影响或交互影响（p>0.05）。