Liu Wan-ning, Jin Lü-wei, Han Dong-wei, Ren Xiao-xuan, Zhu Jiang, Zhang Lu-fen
School of Acu-moxibustion, Beijing University of Chinese Medicine, Beijing 100029, China.
Zhen Ci Yan Jiu. 2009 Dec;34(6):393-7.
To observe the effect of electroacupuncture (EA) of different acupoints on blood pressure (BP), plasma angiotensin (Ang) II, aldosterone (ALD) and atrial natriuretic peptide (ANP) of SHR, so as to observe the relative specificity of effects of acupoints.
A total of 60 SHR were randomly divided into model, Quchi (LI 11), Zusanli (ST 36), Shenmen (HT 7), Jianyu (LI 15) and non-acupoint groups, with 10 cases in each. Other 10 Wistar rats were composed of normal group. EA (2 Hz, 2 mA) was applied to LI 11, ST 36, HT 7, LI 15 and non-acupoint for 30 min, followed by measuring BP with BP-6 system. Plasma Ang II, ALD and ANP contents were assayed by radioimmunoassay.
Compared with control group and pre-treatment, both systolic pressure (SP) and diastolic pressure (DP) of Quchi (LI 11), Zusanli (ST 36) and Shenmen (HT 7) groups lowered significantly (P<0.05). No significant differences were found in the SP and DP of Jianyu (LI 15) and non-acupoint groups (P>0.05). After EA, the SP of Quchi (LI 11) and Shenmen (HT 7) groups were significantly lower than that of Jianyu (LI 15) and non-acupoint groups (P<0.05); and the DP of Quchi (LI 11), Zusanli (ST 36) and Shenmen (HT 7) groups were markedly lower than that of Jianyu (LI 15) and non-acupoint groups (P<0.05). Compared with normal group, the contents of plasma Ang II and ANP of model group decreased significantly, and plasma ALD level of model group increased remarkably (P<0.05). Compared with model group, plasma AngII levels in Quchi (LI 11), Zusanli (ST 36) and Shenmen (HT 7) groups and ALD in Zusanli (ST 36) and Shenmen (HT 7) groups lowered significantly (P<0.05), and plasma ANP content in Shenmen (HT 7) group increased obviously (P<0.05).
EA of LI 11, HT 7 and ST 36 can effectively lowered both DP and SP in SHR, which may be closely related to its effects in regulating the contents of Ang II , ALD and ANP.
观察电针不同穴位对自发性高血压大鼠（SHR）血压（BP）、血浆血管紧张素（Ang）Ⅱ、醛固酮（ALD）和心房钠尿肽（ANP）的影响，以观察穴位效应的相对特异性。
将60只SHR随机分为模型组、曲池（LI 11）组、足三里（ST 36）组、神门（HT 7）组、肩髃（LI 15）组和非穴位组，每组10只。另取10只Wistar大鼠作为正常组。采用2 Hz、2 mA的电针刺激LI 11、ST 36、HT 7、LI 15和非穴位30分钟，随后用BP - 6系统测量血压。采用放射免疫分析法测定血浆AngⅡ、ALD和ANP含量。
与正常组和治疗前相比，曲池（LI 11）组、足三里（ST 36）组和神门（HT 7）组的收缩压（SP）和舒张压（DP）均显著降低（P<0.05）。肩髃（LI 15）组和非穴位组的SP和DP无显著差异（P>0.05）。电针后，曲池（LI 11）组和神门（HT 7）组的SP显著低于肩髃（LI 15）组和非穴位组（P<0.05）；曲池（LI 11）组、足三里（ST 36）组和神门（HT 7）组的DP显著低于肩髃（LI 15）组和非穴位组（P<0.05）。与正常组相比，模型组血浆AngⅡ和ANP含量显著降低，模型组血浆ALD水平显著升高（P<0.05）。与模型组相比，曲池（LI 11）组、足三里（ST 36）组和神门（HT 7）组的血浆AngⅡ水平以及足三里（ST 36）组和神门（HT 7）组的ALD水平显著降低（P<0.05），神门（HT 7）组血浆ANP含量明显升高（P<0.05）。
电针LI 11、HT 7和ST 36可有效降低SHR的DP和SP，这可能与其调节AngⅡ、ALD和ANP含量的作用密切相关。
