Pd(II)催化内炔烃亚胺环化反应通过直接 C-H 键断裂合成咔啉，使用分子氧作为氧化剂。
Pd(II)-catalyzed synthesis of carbolines by iminoannulation of internal alkynes via direct C-H bond cleavage using dioxygen as oxidant.
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191, China.
出版信息
Org Lett. 2010 Apr 2;12(7):1540-3. doi: 10.1021/ol100272s.
PMID:20210308
Abstract
A palladium-catalyzed iminoannulation of internal alkynes via direct C-H bond cleavage was developed. Dioxygen was employed as a clean oxidant in this kind of catalysis. Carbolines were synthesized from tert-butylimines of N-substituted indole-2-carboxaldehydes or indole-3-carboxaldehydes.
摘要
发展了一种钯催化的通过直接 C-H 键断裂的内炔烃亚胺环化反应。在这种催化中，氧气被用作一种清洁的氧化剂。从 N-取代的吲哚-2-甲腈或吲哚-3-甲腈的叔丁基亚胺合成了咔啉类化合物。
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