Vree T B, Vree M L, Benneken Kolmer N, Hekster Y A, Shimoda M
Department of Clinical Pharmacy, Sint Radboud Hospital, Nijmegen, The Netherlands.
Vet Q. 1991 Jan;13(1):60-4. doi: 10.1080/01652176.1991.9694285.
After an oral dose of 100 mg of sulphaphenazole, the turtle Pseudemys scripta elegans excretes 27% of the compound unchanged and 3.8% as N4-acetylsulphaphenazole. The expected glucuronide conjugate, sulphaphenazole-N2-glucuronide, is not formed and excreted.
给予100毫克磺胺苯吡唑口服剂量后,锦龟(Pseudemys scripta elegans)排泄出27%未变化的该化合物,以及3.8%的N4 - 乙酰磺胺苯吡唑。预期的葡糖醛酸缀合物,即磺胺苯吡唑 - N2 - 葡糖醛酸,未形成和排泄。