秀丽锦龟对磺胺-2-单甲氧基嘧啶的O-去烷基化和N4-乙酰化作用
O-Dealkylation and N4-acetylation of sulpha-2-monomethoxine by the turtle Pseudemys scripta elegans.
作者信息
Vree T B, Vree M L, Beneken Kolmer E W, Hekster Y A, Shimoda M, Ono M, Miura T
机构信息
Department of Clinical Pharmacy, Academic Hospital Nijmegen Sint Radboud, The Netherlands.
出版信息
Vet Q. 1991 Jul;13(3):176-80. doi: 10.1080/01652176.1991.9694304.
PMID:1949545
Abstract
Sulpha-2-monomethoxine is N4-acetylated to an extent of 12% of the dose by Pseudemys scripta elegans; 48% is excreted unchanged. No O-dealkylation of the 2-methoxy group takes place.
摘要
秀丽锦龟可将磺胺间甲氧嘧啶N4-乙酰化，其乙酰化程度达给药剂量的12%；48%的药物以原形排泄。2-甲氧基未发生O-脱烷基化反应。
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