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红耳龟体内磺胺甲恶唑和N4-乙酰磺胺甲恶唑的乙酰化、去乙酰化及羟基化作用

Acetylation, deacetylation and hydroxylation of sulphamethoxazole and N4-acetylsulphamethoxazole in the turtle Pseudemys scripta elegans.

作者信息

Vree T B, Vree J B, Hekster Y A, Nouws J F

机构信息

Department of Clinical Pharmacy, St. Radboud Hospital, University of Nijmegen, The Netherlands.

出版信息

Vet Q. 1987 Oct;9(4):381-4. doi: 10.1080/01652176.1987.9694130.

DOI:10.1080/01652176.1987.9694130
PMID:3424645
Abstract

The turtle Pseudemys scripta elegans is able to hydroxylate and acetylate Sulphamethoxazole in a way that is comparable to man, i.e. the rate and yield of hydroxylation equals that of the acetylation. The hydroxy metabolites 5-hydroxy- and N4-acetyl-5-hydroxysulphamethoxazole are not glucuronidated. N4-acetylsulphamethoxazole is neither deacetylated nor hydroxylated.

摘要

秀丽锦龟能够以与人类相当的方式对磺胺甲恶唑进行羟基化和乙酰化，即羟基化的速率和产率与乙酰化的速率和产率相当。羟基代谢物5-羟基磺胺甲恶唑和N4-乙酰基-5-羟基磺胺甲恶唑不会进行葡萄糖醛酸化。N4-乙酰基磺胺甲恶唑既不会脱乙酰化也不会羟基化。

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