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Surprises From Genetic Analyses of Lipid Risk Factors for Atherosclerosis.
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From lipid locus to drug target through human genomics.
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Discovery Approaches for Novel Dyslipidemia Drugs.
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Polygenic modelling of treatment effect heterogeneity.
Genet Epidemiol. 2020 Nov;44(8):868-879. doi: 10.1002/gepi.22347. Epub 2020 Aug 10.
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Association of genetic variants influencing lipid levels with coronary artery disease in Japanese individuals.
PLoS One. 2012;7(9):e46385. doi: 10.1371/journal.pone.0046385. Epub 2012 Sep 26.
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Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations.
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Impact of mifepristone, a glucocorticoid/progesterone antagonist, on HDL cholesterol, HDL particle concentration, and HDL function.
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Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol.
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The genetics of common kidney disease: a pathway toward clinical relevance.
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PON-dering differences in HDL function in coronary artery disease.
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Extended-release niacin or ezetimibe and carotid intima-media thickness.
N Engl J Med. 2009 Nov 26;361(22):2113-22. doi: 10.1056/NEJMoa0907569. Epub 2009 Nov 15.
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Functional lecithin: cholesterol acyltransferase is not required for efficient atheroprotection in humans.
Circulation. 2009 Aug 18;120(7):628-35. doi: 10.1161/CIRCULATIONAHA.108.818143.
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Mendelian randomization: nature's randomized trial in the post-genome era.
JAMA. 2009 Jun 10;301(22):2386-8. doi: 10.1001/jama.2009.812.
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Genetically elevated lipoprotein(a) and increased risk of myocardial infarction.
JAMA. 2009 Jun 10;301(22):2331-9. doi: 10.1001/jama.2009.801.
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A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates.
Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9820-5. doi: 10.1073/pnas.0903849106. Epub 2009 May 14.
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An uncertain future for cardiovascular drug development?
N Engl J Med. 2009 Mar 19;360(12):1169-71. doi: 10.1056/NEJMp0808414.

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