First Dept. of Neurology, Medical School, National & Kapodistrian University of Athens, Greece.
First Dept. of Cardiology, Hippokration Hospital, Medical School, National & Kapodistrian University of Athens, Greece.
Int J Cardiol. 2010 Nov 19;145(2):386-387. doi: 10.1016/j.ijcard.2010.02.056. Epub 2010 Mar 7.
Interatrial block is a predictor of atrial arrhythmias. Aim of the present study was to estimate the prevalence of interatrial block (IAB) in Friedreich's Ataxia (FA) compared to controls and correlate it with echocardiographic and genetic features.
IAB, defined as an electrocardiographic (ECG) derived P-wave duration >120 ms, echocardiographic variables and genetic markers were evaluated in 23 FA patients with no manifestation of cardiac involvement and were compared to 23 sex- and age-matched controls.
IAB was significantly more frequent among FA patients compared to controls (11/23 vs 1/23, p<0.005 respectively). However, no correlations with echocardiographic parameters or Guanine-Adenine-Adenine (GAA) trinucleotide repeat lengths could be established.
Early recognition of IAB could allow the identification of asymptomatic FA patients who are prone to develop potentially life-threatening arrhythmias.
房内阻滞是心房心律失常的预测因子。本研究旨在评估 Friedreich 共济失调（FA）患者与对照组相比房内阻滞（IAB）的发生率，并将其与超声心动图和遗传特征相关联。
评估了 23 例无心脏受累表现的 FA 患者的 IAB（定义为心电图衍生的 P 波持续时间>120ms）、超声心动图变量和遗传标志物，并与 23 名性别和年龄匹配的对照组进行比较。
与对照组相比，FA 患者的 IAB 发生率显著更高（11/23 比 1/23，分别为 p<0.005）。然而，与超声心动图参数或鸟嘌呤-腺嘌呤-腺嘌呤（GAA）三核苷酸重复长度均无相关性。
早期识别 IAB 可识别易发生潜在危及生命的心律失常的无症状 FA 患者。
