Pan Xianglong, Hao Erwei, Zhang Fan, Wei Wei, Du Zhengcai, Yan Guangli, Wang Xijun, Deng Jiagang, Hou Xiaotao
Department of Pharmaceutical, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
Front Pharmacol. 2024 Jul 9;15:1401961. doi: 10.3389/fphar.2024.1401961. eCollection 2024.
Diabetic cardiomyopathy (DCM) is a specific heart condition in diabetic patients, which is a major cause of heart failure and significantly affects quality of life. DCM is manifested as abnormal cardiac structure and function in the absence of ischaemic or hypertensive heart disease in individuals with diabetes. Although the development of DCM involves multiple pathological mechanisms, mitochondrial dysfunction is considered to play a crucial role. The regulatory mechanisms of mitochondrial dysfunction mainly include mitochondrial dynamics, oxidative stress, calcium handling, uncoupling, biogenesis, mitophagy, and insulin signaling. Targeting mitochondrial function in the treatment of DCM has attracted increasing attention. Studies have shown that plant secondary metabolites contribute to improving mitochondrial function and alleviating the development of DCM. This review outlines the role of mitochondrial dysfunction in the pathogenesis of DCM and discusses the regulatory mechanism for mitochondrial dysfunction. In addition, it also summarizes treatment strategies based on plant secondary metabolites. These strategies targeting the treatment of mitochondrial dysfunction may help prevent and treat DCM.
糖尿病性心肌病（DCM）是糖尿病患者特有的一种心脏疾病，是心力衰竭的主要原因，严重影响生活质量。DCM表现为糖尿病患者在无缺血性或高血压性心脏病的情况下心脏结构和功能异常。尽管DCM的发展涉及多种病理机制，但线粒体功能障碍被认为起着关键作用。线粒体功能障碍的调节机制主要包括线粒体动力学、氧化应激、钙处理、解偶联、生物发生、线粒体自噬和胰岛素信号传导。针对线粒体功能治疗DCM已引起越来越多的关注。研究表明，植物次生代谢产物有助于改善线粒体功能并减轻DCM的发展。本综述概述了线粒体功能障碍在DCM发病机制中的作用，并讨论了线粒体功能障碍的调节机制。此外，还总结了基于植物次生代谢产物的治疗策略。这些针对线粒体功能障碍治疗的策略可能有助于预防和治疗DCM。
