Commonwealth Scientific Industrial Research Organisation (CSIRO), Food and Nutritional Sciences, Adelaide BC, South Australia, Australia.
Eur J Endocrinol. 2010 Jun;162(6):1075-82. doi: 10.1530/EJE-10-0062. Epub 2010 Mar 8.
Obesity is associated with major changes in the circulating IGF system. However, it is not clear to what extent the IGF system is normalized following diet, and the possible role of different types of diet is also unknown.
To compare changes in the circulating IGF system following 12 weeks of moderate energy restriction (7000 kJ/day) in overweight or obese males on a high protein high red meat diet (HP) or a high carbohydrate diet (HC).
Seventy-six men (mean age, 51+/-1.0 years; body mass index, 32.8+/-0.5 kg/m(2)) were allocated to matched groups treated with isocaloric diets of HP (n=34) or HC (n=42). Outcome measures were weight, body composition, IGF-related peptides, homoeostasis model assessment of insulin resistance (HOMA1-IR) and adipokines.
Weight loss did not differ between diets (HP 8.5+/-0.6 kg; HC 8.2+/-0.6 kg, P>0.05). IGF-related peptides increased total IGF1 (HP 23%; HC 18%, P<0.0001), bioactive IGF1 (HP 18%; HC 15%, P<0.002), IGF1:IGF-binding protein-3 (IGFBP-3; HP 29%; HC 22%, P<0.0001) and IGFBP-1 (HP 24%; HC 25%, P<0.01). By contrast, decreases were observed in IGFBP-3 (HP -4%; HC -3%, P<0.01), pro-IGF2 (HP -3%; HC -6%, P=0.001), total IGF2 (HP -7%; HC -3%, P=0.001) and sIGF2R (HP -10%; HC -6%, P<0.005). Only IGFBP-2 increased differentially by diet (HP 34%; HC 50%, P<0.0001, diet P<0.05). Adiponectin increased in both diets, but leptin and HOMA-IR decreased (P<0.001).
Weight loss induced by moderate energy restriction modulated the IGF system independent of dietary protein or red meat content. The effect of diet on IGFBP-2 appeared to have limited biological effect as total IGF2 and pro-IGF2 did not change.
肥胖与循环 IGF 系统的重大变化有关。然而，尚不清楚饮食干预后 IGF 系统在多大程度上恢复正常，不同类型饮食的可能作用也不清楚。
比较超重或肥胖男性在接受高蛋白高脂肪（HP）饮食或高碳水化合物（HC）饮食 12 周后，循环 IGF 系统的变化。
76 名男性（平均年龄 51+/-1.0 岁；体重指数 32.8+/-0.5kg/m(2)) 被分为两组，接受等热量的 HP（n=34）或 HC（n=42）饮食治疗。观察指标为体重、身体成分、IGF 相关肽、稳态模型评估的胰岛素抵抗（HOMA1-IR）和脂肪因子。
两种饮食的体重减轻无差异（HP 8.5+/-0.6kg；HC 8.2+/-0.6kg，P>0.05）。IGF 相关肽增加总 IGF1（HP 23%；HC 18%，P<0.0001）、生物活性 IGF1（HP 18%；HC 15%，P<0.002）、IGF1:IGF 结合蛋白-3（IGFBP-3；HP 29%；HC 22%，P<0.0001）和 IGFBP-1（HP 24%；HC 25%，P<0.01）。相反，IGFBP-3（HP -4%；HC -3%，P<0.01）、前 IGF2（HP -3%；HC -6%，P=0.001）、总 IGF2（HP -7%；HC -3%，P=0.001）和 sIGF2R（HP -10%；HC -6%，P<0.005）则减少。只有 IGFBP-2 因饮食而不同（HP 34%；HC 50%，P<0.0001，饮食 P<0.05）。两种饮食均使脂联素增加，但瘦素和 HOMA-IR 降低（P<0.001）。
中等能量限制引起的体重减轻独立于饮食蛋白或红肉含量调节 IGF 系统。饮食对 IGFBP-2 的影响似乎没有生物学意义，因为总 IGF2 和前 IGF2 没有变化。
