Department of Nutrition and Dietetics, American University of Madaba, Madaba P.O. Box 2882, Jordan.
Division of Cancer Prevention and Control, Department of Internal Medicine, The Ohio State University, Columbus, OH 43214, USA.
Nutrients. 2024 Oct 14;16(20):3476. doi: 10.3390/nu16203476.
Obesity is associated with alterations in circulating IGF1, IGF1-binding proteins (IGFBPs), insulin, inflammatory markers, and hormones implicated in cardiovascular disease, diabetes, cancer, and aging. However, the effects of 4 and 6 h time-restricted eating (TRE) on circulating IGF1 and IGFBPs is uncertain.
This study aimed to investigate the effects of TRE on plasma IGF1, IGFBP1, IGFBP2, and IGFBP3, and whether these effects were mediated by weight loss or body composition changes. Insulin sensitivity, glucose control, adipokines, and inflammatory markers were also examined.
An exploratory analysis of an 8-week randomized controlled trial implementing a daily TRE intervention was carried out.
PARTICIPANTS/SETTING: This study was conducted at the University of Illinois at Chicago in 2019. Participants with obesity were randomized to 4 or 6 h TRE (n = 35) or a control (n = 14) group. Plasma biomarkers were measured by ELISA at baseline and week 8. In a sub-analysis, participants were stratified into higher- (>3.5%) and lower- (≤3.5%) weight-loss groups.
Participants fasted daily from 7 p.m. to 3 p.m. in the 4 h TRE group (20 h) and from 7 p.m. to 1 p.m. in the 6 h TRE group (18 h), followed by ad libitum eating for the remainder of the day. Controls received no dietary recommendations.
IGF1, IGFBPs, hsCRP, and adipokines were the main outcome measures of this analysis.
Repeated measures ANOVA and mediation analysis were conducted.
Body weight significantly decreased with TRE (-3.6 ± 0.3%), contrasting with controls (+0.2 ± 0.5%, < 0.001). Significant effects of TRE over time were observed on plasma IGFBP2, insulin, HOMA-IR, and 8-isoprostane levels, without affecting other biomarkers. In the sub-analysis, IGFBP2 increased while leptin and 8-isoprostane decreased significantly only in the "higher weight loss" subgroup. Changes in insulin and HOMA-IR were related to TRE adherence.
Eight-week daily 4 to 6 h TRE did not affect IGF1, IGFBP1, or IGFBP3 levels but improved insulin, HOMA-IR, and 8-isoprostane. IGFBP2 increased and leptin decreased when weight loss exceeded 3.5% of baseline.
本研究旨在探讨限时进食（TRE）对血浆 IGF1、IGFBP1、IGFBP2 和 IGFBP3 的影响，以及这些影响是否通过体重减轻或身体成分变化介导。还检查了胰岛素敏感性、血糖控制、脂肪因子和炎症标志物。
对实施每日 TRE 干预的 8 周随机对照试验进行了探索性分析。
参与者/设置：本研究于 2019 年在伊利诺伊大学芝加哥分校进行。肥胖参与者被随机分为 4 或 6 小时 TRE（n=35）或对照组（n=14）。基线和第 8 周通过 ELISA 测量血浆生物标志物。在亚分析中，参与者被分为更高（>3.5%）和更低（≤3.5%）体重减轻组。
4 小时 TRE 组（20 小时）参与者每天从下午 7 点禁食至下午 3 点，6 小时 TRE 组（18 小时）从下午 7 点禁食至下午 1 点，然后在当天的剩余时间自由进食。对照组未接受饮食建议。
IGF1、IGFBP、hsCRP 和脂肪因子是本分析的主要观察指标。
进行了重复测量方差分析和中介分析。
与对照组（+0.2 ± 0.5%，<0.001）相比，TRE 显著降低了体重（-3.6 ± 0.3%）。TRE 随时间的显著影响观察到在血浆 IGFBP2、胰岛素、HOMA-IR 和 8-异前列腺素水平，而不影响其他生物标志物。在亚分析中，仅在“更高体重减轻”亚组中，IGFBP2 增加，而瘦素和 8-异前列腺素显著降低。胰岛素和 HOMA-IR 的变化与 TRE 依从性有关。
为期 8 周的每日 4 至 6 小时 TRE 并未影响 IGF1、IGFBP1 或 IGFBP3 水平，但改善了胰岛素、HOMA-IR 和 8-异前列腺素。当体重减轻超过基线的 3.5%时，IGFBP2 增加，瘦素减少。
