过硫酸化硫酸软骨素并非肝素中的唯一污染物。 - Suppr

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超能文献

Oversulfated chondroitin sulfate is not the sole contaminant in heparin.

作者信息

Pan Jing, Qian Yi, Zhou Xiaodong, Pazandak Andrew, Frazier Sarah B, Weiser Peter, Lu Hong, Zhang Lijuan

出版信息

Nat Biotechnol. 2010 Mar;28(3):203-7; author reply 207-11. doi: 10.1038/nbt0310-203.

DOI:10.1038/nbt0310-203

PMID:20212477

Abstract

摘要

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本文引用的文献

Identification of Chemically Sulfated/desulfated Glycosaminoglycans in Contaminated Heparins and Development of a Simple Assay for the Detection of Most Contaminants in Heparin.污染肝素中化学硫酸化/去硫酸化糖胺聚糖的鉴定及一种检测肝素中大多数污染物的简易测定法的开发

Glycobiol Insights. 2010 Feb 2;2010(2):1-12.

The Quantification of Glycosaminoglycans: A Comparison of HPLC, Carbazole, and Alcian Blue Methods.糖胺聚糖的定量分析：高效液相色谱法、咔唑法和阿尔辛蓝法的比较

Open Glycosci. 2008 Jan 1;1:31-39. doi: 10.2174/1875398100801010031.

Orthogonal analytical approaches to detect potential contaminants in heparin.肝素中潜在污染物的正交分析方法。

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):16956-61. doi: 10.1073/pnas.0906861106. Epub 2009 Sep 23.

Analysis of pharmaceutical heparins and potential contaminants using (1)H-NMR and PAGE.采用（1）H-NMR 和 PAGE 分析药物肝素及其潜在污染物。

J Pharm Sci. 2009 Nov;98(11):4017-26. doi: 10.1002/jps.21729.

Lessons learned from the contamination of heparin.从肝素污染事件中吸取的教训。

Nat Prod Rep. 2009 Mar;26(3):313-21. doi: 10.1039/b819896a. Epub 2009 Jan 19.

Quantitative capillary electrophoresis determination of oversulfated chondroitin sulfate as a contaminant in heparin preparations.定量毛细管电泳法测定肝素制剂中的过度硫酸化软骨素硫酸盐作为污染物。

Anal Biochem. 2009 May 1;388(1):140-5. doi: 10.1016/j.ab.2009.02.012. Epub 2009 Feb 14.

Contaminants in heparins continue to be unfolded.肝素中的污染物仍在不断被揭示。

Int Angiol. 2008 Dec;27(6):457-61.

Outbreak of adverse reactions associated with contaminated heparin.与受污染肝素相关的不良反应暴发。

N Engl J Med. 2008 Dec 18;359(25):2674-84. doi: 10.1056/NEJMoa0806450. Epub 2008 Dec 3.

Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events.过度硫酸化硫酸软骨素是肝素中的一种污染物，与不良临床事件相关。

Nat Biotechnol. 2008 Jun;26(6):669-75. doi: 10.1038/nbt1407. Epub 2008 Apr 23.

Contaminated heparin associated with adverse clinical events and activation of the contact system.受污染的肝素与不良临床事件及接触系统激活相关。

N Engl J Med. 2008 Jun 5;358(23):2457-67. doi: 10.1056/NEJMoa0803200. Epub 2008 Apr 23.

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