关节内注射醋酸甲基泼尼松龙对正常马关节软骨的影响。

Effects of intra-articular administration of methylprednisolone acetate on normal equine articular cartilage.

作者信息

Trotter G W, McIlwraith C W, Yovich J V, Norrdin R W, Wrigley R H, Lamar C H

机构信息

Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.

出版信息

Am J Vet Res. 1991 Jan;52(1):83-7.

PMID:2021259

Abstract

The effects of the corticosteroid 6-alpha-methylprednisolone acetate on normal equine articular cartilage were evaluated, using the middle carpal joint in 4 clinically normal young horses. One middle carpal joint of each horse was injected 3 times with 100 mg of 6-alpha-methylprednisolone acetate, at 14-day intervals. The opposite middle carpal joint (control) was injected with 2.5 ml of lactated Ringer solution at the same intervals. Effects were studied until 8 weeks after the first injection. Evaluation included clinical and radiographic examination, and gross, microscopic, and biochemical evaluation of joint tissues. Horses remained clinically normal during the study, and significant radiographic changes were not observed. Safranin-0 matrix staining intensity and uronic acid content were significantly (P less than 0.05) lower and hydroxyproline content was significantly (P less than 0.05) higher in articular cartilage of corticosteroid-injected joints vs control joints.

摘要

使用4匹临床健康的年轻马的腕中关节，评估皮质类固醇6-α-甲基泼尼松龙醋酸酯对正常马关节软骨的影响。每匹马的一个腕中关节每隔14天注射3次100mg的6-α-甲基泼尼松龙醋酸酯。相对的腕中关节（对照）以相同的间隔注射2.5ml乳酸林格氏液。研究效果直至首次注射后8周。评估包括临床和放射学检查，以及关节组织的大体、显微镜和生化评估。在研究期间马匹保持临床健康，未观察到明显的放射学变化。与对照关节相比，注射皮质类固醇关节的关节软骨中番红O基质染色强度和糖醛酸含量显著降低（P<0.05），羟脯氨酸含量显著升高（P<0.05）。