Department of Physiology, Georgetown University Medical Center, Basic Science Building, Room 231B, 3900 Reservoir Road, N.W., Washington, DC 20057, USA.
Mol Cell Biochem. 2010 Jul;340(1-2):169-73. doi: 10.1007/s11010-010-0414-9. Epub 2010 Mar 7.
The healthful benefits of two commercially available formulations of coenzyme Q10 (Co Q10), one in gel and the other in a powdered form, on a variety of metabolic parameters in Sprague-Dawley rats (SD) were compared to control. The principal metabolic parameters examined were systolic blood pressure (SBP), DNA fragmentation, and free radical formation in hepatic and renal tissues. Compared to control, the powdered formulation significantly decreased SBP in the normotensive SD, whereas both commercial formulations lowered hepatic and renal DNA fragmentation and free radical formation. The gel-formulation lowered hepatic DNA fragmentation more than the powdered-formulation. In conclusion, both gel- and powdered-formulations of Co Q10 significantly influenced the metabolic parameters assessed in a favorable fashion, with the powdered-formulation more effective on SBP and the gel-formulation more effective on overcoming hepatic DNA fragmentation. From the data, we conclude that the choice of the formulation containing Co Q10 to be used should be based on the desired healthful benefits.
将两种市售的辅酶 Q10（Co Q10）制剂（一种凝胶形式，另一种粉末形式）对 Sprague-Dawley 大鼠（SD）的各种代谢参数的健康益处与对照组进行了比较。检查的主要代谢参数是收缩压（SBP）、肝和肾组织中的 DNA 片段化和自由基形成。与对照组相比，粉末制剂显著降低了正常血压 SD 的 SBP，而两种商业制剂均降低了肝和肾的 DNA 片段化和自由基形成。凝胶制剂降低肝 DNA 片段化的效果优于粉末制剂。总之，Co Q10 的凝胶和粉末两种制剂都以有利的方式显著影响了所评估的代谢参数，其中粉末制剂对 SBP 的作用更有效，凝胶制剂对克服肝 DNA 片段化的作用更有效。根据这些数据，我们得出结论，应根据所需的健康益处选择要使用的 Co Q10 制剂。
