Razi Herbal Researches Center, Lorestan University of Medical Sciences , Khoram Abad , Iran .
Ren Fail. 2014 Apr;36(3):413-8. doi: 10.3109/0886022X.2013.865154. Epub 2013 Dec 9.
Coenzyme Q10 is a natural antioxidant and scavenger of free radicals. In the present study, we examined the effect of coenzyme Q10 on paraoxonase 1 (PON1) activity, lipid profile, atherogenic indexes and relationship of PON 1 activity by high-density lipoprotein (HDL) and atherogenic indexes in gentamicin (GM)-induced nephrotoxicity rats. Thirty Sprague-Dawley rats were divided into three groups to receive saline; GM, 100 mg/kg/d; and GM plus coenzyme Q10 by 15 mg/kg i.p daily, respectively. After 12 days, animals were anaesthetized, blood samples were also collected before killing to measure the levels of triglyceride (TG), cholesterol (C), low-density lipoprotein (LDL), very low density lipoprotein (VLDL), HDL, atherogenic indexes and the activities of PON1 of all groups were analyzed. Data were analyzed by non-parametric Mann-Whitney test (using SPSS 13 software). Coenzyme Q10 significantly decreased TG, C, LDL, VLDL, atherogenic index, atherogenic coefficient and cardiac risk ratio. HDL level and PON1 activity were significantly increased when treated with coenzyme Q10. Also, the activity of PON 1 correlated positively with HDL and negatively with atherogenic coefficient, cardiac risk ratio 1 and cardiac risk ratio 2. This study showed that coenzyme Q10 exerts beneficial effects on PON1 activity, lipid profile, atherogenic index and correlation of PON 1 activity with HDL and atherogenic index in GM -induced nephrotoxicity rats.
辅酶 Q10 是一种天然抗氧化剂和自由基清除剂。在本研究中，我们研究了辅酶 Q10 对 对氧磷酶 1（PON1）活性、血脂谱、动脉粥样硬化指数以及 PON1 活性与高密度脂蛋白（HDL）和动脉粥样硬化指数之间关系的影响在庆大霉素（GM）诱导的肾病大鼠中。将 30 只 Sprague-Dawley 大鼠分为三组，分别给予生理盐水；GM，100mg/kg/d；和 GM 加辅酶 Q10，每天 15mg/kg 腹腔注射。12 天后，动物麻醉，处死前采集血液样本，测量甘油三酯（TG）、胆固醇（C）、低密度脂蛋白（LDL）、极低密度脂蛋白（VLDL）、HDL、动脉粥样硬化指数和各组 PON1 的活性。数据采用非参数 Mann-Whitney 检验（使用 SPSS 13 软件）进行分析。辅酶 Q10 可显著降低 TG、C、LDL、VLDL、动脉粥样硬化指数、动脉粥样硬化系数和心脏风险比。当用辅酶 Q10 治疗时，HDL 水平和 PON1 活性显著增加。此外，PON1 活性与 HDL 呈正相关，与动脉粥样硬化系数、心脏风险比 1 和心脏风险比 2 呈负相关。本研究表明，辅酶 Q10 对 GM 诱导的肾病大鼠 PON1 活性、血脂谱、动脉粥样硬化指数以及 PON1 活性与 HDL 和动脉粥样硬化指数之间的相关性具有有益作用。
