Goris R J, van Bebber I P, Mollen R M, Koopman J P
Department of General Surgery, University Hospital St Radboud, Nijmegen, The Netherlands.
Arch Surg. 1991 May;126(5):561-5. doi: 10.1001/archsurg.1991.01410290033006.
Gut bacteria have been incriminated as causing or contributing to generalized sepsis with multiple organ failure in severely ill patients, and selective decontamination of the gastrointestinal tract of Enterobacteriaceae has been claimed to decrease septic complications in these patients. We studied the effects of selective decontamination of the gastrointestinal tract on survival and organ function in an experimental model of sepsis with multiple organ failure. Wistar rats were inoculated intraperitoneally with zymosan and randomized into control or treatment groups (trimethoprim or streptomycin sulfate). Selective decontamination effectively prevented bacterial translocation of Enterobacteriaceae. However, only early mortality was decreased, and only so in the streptomycin-treated rats. Selective decontamination did not result in a significantly better condition of the surviving animals on day 12.
肠道细菌被认为是导致重症患者发生全身性脓毒症并伴有多器官功能衰竭的原因之一，而对肠道进行肠杆菌科细菌的选择性去污处理被认为可以减少这些患者的脓毒症并发症。我们在一个伴有多器官功能衰竭的脓毒症实验模型中研究了胃肠道选择性去污处理对生存和器官功能的影响。将酵母聚糖腹腔注射接种到Wistar大鼠体内，并随机分为对照组或治疗组（甲氧苄啶或硫酸链霉素）。选择性去污处理有效地防止了肠杆菌科细菌的易位。然而，仅早期死亡率有所降低，且仅在链霉素治疗的大鼠中如此。在第12天，选择性去污处理并未使存活动物的状况显著改善。
