多器官功能衰竭的介质
Mediators of multiple organ failure.
作者信息
Goris R J
机构信息
Department of General Surgery, University Hospital St. Radboud, Nijmegen, The Netherlands.
出版信息
Intensive Care Med. 1990;16 Suppl 3(Suppl 3):S192-6. doi: 10.1007/BF01709699.
Abstract
Multiple Organ Failure (MOF) has largely been attributed to bacterial sepsis, though conclusive evidence of an essential role for bacteria and/or their endotoxins is still lacking. On the other hand, MOF and the clinical syndrome of sepsis may be aseptically induced in germ-free animals. This paper reviews the evidence that excessive activation of endogenous humoral mediators and inflammatory cells may cause this highly lethal syndrome.
摘要
多器官功能衰竭（MOF）在很大程度上被归因于细菌性败血症，尽管仍缺乏关于细菌和/或其内毒素起关键作用的确凿证据。另一方面，MOF和败血症临床综合征可在无菌动物中无菌诱导产生。本文综述了内源性体液介质和炎症细胞过度激活可能导致这种高致死性综合征的证据。
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