多器官功能衰竭的介质
Mediators of multiple organ failure.
作者信息
Goris R J
机构信息
Department of General Surgery, University Hospital St. Radboud, Nijmegen, The Netherlands.
出版信息
Intensive Care Med. 1990;16 Suppl 3(Suppl 3):S192-6. doi: 10.1007/BF01709699.
Abstract
Multiple Organ Failure (MOF) has largely been attributed to bacterial sepsis, though conclusive evidence of an essential role for bacteria and/or their endotoxins is still lacking. On the other hand, MOF and the clinical syndrome of sepsis may be aseptically induced in germ-free animals. This paper reviews the evidence that excessive activation of endogenous humoral mediators and inflammatory cells may cause this highly lethal syndrome.
摘要
多器官功能衰竭（MOF）在很大程度上被归因于细菌性败血症，尽管仍缺乏关于细菌和/或其内毒素起关键作用的确凿证据。另一方面，MOF和败血症临床综合征可在无菌动物中无菌诱导产生。本文综述了内源性体液介质和炎症细胞过度激活可能导致这种高致死性综合征的证据。
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本文引用的文献
1
Control of vascular permeability by polymorphonuclear leukocytes in inflammation.炎症中多形核白细胞对血管通透性的控制
Nature. 1981 Feb 19;289(5799):646-50. doi: 10.1038/289646a0.
2
Leukocytes are required for increased lung microvascular permeability after microembolization in sheep.绵羊微栓塞后肺微血管通透性增加需要白细胞。
Circ Res. 1981 Mar;48(3):344-51. doi: 10.1161/01.res.48.3.344.
3
Effect of nonviable tissue and abscesses on complement depletion and the development of bacteremia.无活力组织和脓肿对补体消耗及菌血症发生的影响。
J Trauma. 1982 Jul;22(7):527-32. doi: 10.1097/00005373-198207000-00001.
4
Increase in microvascular permeability induced by enzymatically generated free radicals. I. In vivo study.酶促产生的自由基诱导的微血管通透性增加。I. 体内研究。
Microvasc Res. 1981 Nov;22(3):239-54. doi: 10.1016/0026-2862(81)90095-9.
5
Complement activation in patients at risk of developing the adult respiratory distress syndrome.有发生成人呼吸窘迫综合征风险的患者体内的补体激活
Am Rev Respir Dis. 1984 Dec;130(6):1058-64. doi: 10.1164/arrd.1984.130.6.1058.
6
Interleukin-1.白细胞介素-1
Rev Infect Dis. 1984 Jan-Feb;6(1):51-95. doi: 10.1093/clinids/6.1.51.
7
Anaphylatoxin generation in multisystem organ failure.多系统器官衰竭中的过敏毒素生成
J Trauma. 1984 Dec;24(12):1038-43. doi: 10.1097/00005373-198412000-00006.
8
Human C5a des Arg increases vascular permeability.人C5a去精氨酸产物可增加血管通透性。
J Immunol. 1981 Dec;127(6):2376-80.
9
Association of complement activation and elevated plasma-C5a with adult respiratory distress syndrome. Pathophysiological relevance and possible prognostic value.补体激活及血浆C5a升高与成人呼吸窘迫综合征的关联。病理生理相关性及可能的预后价值。
Lancet. 1980 May 3;1(8175):947-9. doi: 10.1016/s0140-6736(80)91403-8.
10
Sepsis complicating the acute respiratory distress syndrome.脓毒症并发急性呼吸窘迫综合征。
Surg Gynecol Obstet. 1972 Dec;135(6):865-9.
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