Leung Ki E L, Roduit J, Delarive J, Guyot J, Michetti P, Dorta G
Service de Gastro-Entérologie et D'Hepatologie, CHUV.
Rev Med Suisse. 2010 Jan 27;6(233):186-8, 190-1.
Small intestine bacterial overgrowth (SIBO) is a condition characterised by nutrient malabsorption and excessive bacteria in the small intestine. It typically presents with diarrhea, flatulence and a syndrome of malabsorption (steatorrhea, macrocytic anemia). However, it may be asymptomatic in the eldery. A high index of suspicion is necessary in order to differentiate SIBO from other similar presenting disorders such as coeliac disease, lactose intolerance or the irritable bowel syndrome. A search for predisposing factor is thus necessary. These factors may be anatomical (stenosis, blind loop), or functional (intestinal hypomotility, achlorydria). The hydrogen breath test is the most frequently used diagnostic test although it lacks standardisation. The treatment of SIBO consists of eliminating predisposing factors and broad-spectrum antibiotic therapy.
小肠细菌过度生长(SIBO)是一种以营养吸收不良和小肠细菌过多为特征的病症。它通常表现为腹泻、肠胃胀气和吸收不良综合征(脂肪泻、大细胞性贫血)。然而,在老年人中可能无症状。为了将SIBO与其他表现相似的疾病如乳糜泻、乳糖不耐受或肠易激综合征区分开来,需要高度怀疑。因此,有必要寻找诱发因素。这些因素可能是解剖学上的(狭窄、盲袢),或功能性的(肠道动力不足、胃酸缺乏)。氢呼气试验是最常用的诊断测试,尽管它缺乏标准化。SIBO的治疗包括消除诱发因素和广谱抗生素治疗。