Department of Medicine, University of California, San Diego, 92161, USA.
Curr Drug Metab. 2009 Oct;10(8):875-84. doi: 10.2174/138920009790274522.
Staphylococcal infection can cause a wide range of diseases resulting either from staphylococcal bacteria invasion or through toxin production. The majority of infections caused by staphylococci are due to Staphylococcus aureus. Moreover, methicillin-resistant Staphylococcus aureus has recently been considered to be one of the major causes of hospital-acquired infections. The treatment of staphylococci infections is difficult because increased antibiotic resistant strains have become more common, increasing the risk of serious health penalty. Delivery of antibiotics via nanoparticles is a promising therapy, as a drug delivery mechanism, particularly for controlled release or depot delivery of drugs to decrease the number of doses required to achieve a clinical effect. This review emphasized the potential of nanoparticles in the targeted antibiotics for therapy of staphylococcal infections.
葡萄球菌感染可引起多种疾病，这些疾病可能由葡萄球菌的侵袭或通过毒素的产生引起。大多数由葡萄球菌引起的感染是由金黄色葡萄球菌引起的。此外，耐甲氧西林金黄色葡萄球菌最近被认为是医院获得性感染的主要原因之一。葡萄球菌感染的治疗很困难，因为抗生素耐药株越来越常见，增加了严重健康损害的风险。纳米颗粒输送抗生素是一种很有前途的治疗方法，作为一种药物输送机制，特别是用于控制药物的释放或储存，以减少达到临床效果所需的剂量数。本综述强调了纳米颗粒在靶向抗生素治疗葡萄球菌感染方面的潜力。
