用于递送治疗剂和成像剂的纳米级自组装
NANOSCALE SELF-ASSEMBLY FOR DELIVERY OF THERAPEUTICS AND IMAGING AGENTS.
作者信息
Chen Mingnan, McDaniel Jonathan R, Mackay J Andrew, Chilkoti Ashutosh
机构信息
Department of Biomedical Engineering, Duke University, Durham, NC, USA.
出版信息
Technol Innov. 2011 Jan 1;13(1):5-25. doi: 10.3727/194982411X13003853539948.
Self-assemblies are complex structures spontaneously organized from simpler subcomponents, primarily through noncovalent interactions. These structures are being exploited as delivery vehicles of therapeutic and imaging agents. They have two unique advantages in comparison to other vehicles: 1) they are able to assume complex structures that are difficult to attain by chemical synthesis, and 2) the dissociation of self-assembled structures can be triggered by external stimuli, which can serve as a mechanism of payload release. In this review, we discuss two naturally occurring (proteins and viral capsids) and five engineered self-assemblies (vesicles, micelles, proteins, hydrogels, and inclusion complexes) that are under development for delivery of drugs and imaging agents. For each class of self-assembled supramolecular structures, we examine its structural and physicochemical properties, and potential applications within the context of assembly, loading, and payload release.
自组装体是由更简单的亚组分主要通过非共价相互作用自发组织形成的复杂结构。这些结构正被用作治疗剂和成像剂的递送载体。与其他载体相比，它们具有两个独特的优势：1）它们能够呈现出化学合成难以实现的复杂结构，2）自组装结构的解离可以由外部刺激触发，这可以作为负载释放的一种机制。在本综述中，我们讨论了正在开发用于药物和成像剂递送的两种天然存在的（蛋白质和病毒衣壳）以及五种工程化自组装体（囊泡、胶束、蛋白质、水凝胶和包合物）。对于每一类自组装超分子结构，我们在组装、负载和负载释放的背景下研究其结构和物理化学性质以及潜在应用。
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