Tano J Y, Smedlund K, Vazquez G
Department of Physiology and Pharmacology, Center for Diabetes and Endocrine Research, College of Medicine, University of Toledo Health Science Campus, 3000 Arlington Ave., Toledo, OH 43614-5804, USA.
Cardiovasc Hematol Agents Med Chem. 2010 Jan;8(1):76-86. doi: 10.2174/187152510790796138.
An impressive amount of experimental evidence accumulated over the last two decades has clearly demonstrated that Ca(2+) influx through plasma membrane Ca(2+)-permeable channels plays a critical role in endothelial cell physiology and pathophysiology. Research efforts aimed at understanding the role of Ca(2+) influx within the signaling events underlying endothelial dysfunction have grown at a fast pace over more recent years. Transient Receptor Potential Canonical (TRPC) proteins, which belong to the larger TRP superfamily of channel forming proteins, form Ca(2+)-permeable cation channels in vascular endothelium and there is currently no question about their involvement in Ca(2+) influx associated with endothelial cell's physiology. It is also becoming evident that TRPCs are important players in the pathogenesis of cardiovascular disease. Therefore, it is imperative to elucidate the mechanism/s underlying regulation of endothelial TRPC channels as well as to identify signaling events downstream TRPC activation in order to better comprehend their role in cardiovascular physiology and disease. This review focuses on members of the TRPC3/6/7 group of TRPC proteins, revises current knowledge on their expression and regulation in endothelium, and discusses their role in cardiovascular disease as it relates to endothelial dysfunction.
在过去二十年中积累的大量实验证据清楚地表明，通过质膜钙渗透通道的Ca(2+)内流在内皮细胞的生理和病理生理过程中起着关键作用。近年来，旨在了解Ca(2+)内流在内皮功能障碍潜在信号事件中的作用的研究工作迅速增加。瞬时受体电位经典型（TRPC）蛋白属于更大的通道形成蛋白TRP超家族，在血管内皮中形成钙渗透阳离子通道，目前毫无疑问它们参与了与内皮细胞生理相关的Ca(2+)内流。同样明显的是，TRPCs在心血管疾病的发病机制中起着重要作用。因此，阐明内皮TRPC通道的调控机制以及确定TRPC激活后的信号事件，对于更好地理解它们在心血管生理和疾病中的作用至关重要。本综述重点关注TRPC蛋白的TRPC3/6/7组成员，回顾了目前关于它们在内皮中的表达和调控的知识，并讨论了它们在与内皮功能障碍相关的心血管疾病中的作用。
