Vazquez Guillermo
Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, Ohio 43614, USA.
Front Biosci (Schol Ed). 2012 Jan 1;4(1):157-66. doi: 10.2741/258.
Transient Receptor Potential Canonical (TRPC) proteins are non-selective cation channels ubiquitously expressed throughout the cardiovascular system, where they participate as Ca2+/Na+-permeable channels and/or signaling platforms in various physiological and pathophysiological mechanisms. TRPCs have been implicated in essential hypertension, cardiac hypertrophy and endothelial dysfunction. Despite these pathologies being related, directly or indirectly to development of atherosclerotic lesions, the potential role of TRPCs in the pathogenesis of atherosclerosis remains unexplored. Recent studies from our laboratory showing an obligatory requirement of TRPC3 in the inflammatory signaling linked to monocycle recruitment to coronary endothelium, suggest for the first time potential pathophysiological relevance of a member of the TRPC group in atherogenesis. This brings about the question whether we can envision TRPCs as potential targets for diagnosis, prognosis and/or treatment of atherosclerosis. Here we revisit some of the existing knowledge on TRPCs and cardiovascular pathology and discuss it within the context of cellular/molecular processes related to atherogenesis. Potential limitations and advantages of TRPCs as prospectives targets in atherosclerosis are discussed and confronted against.
瞬时受体电位香草酸亚家族（TRPC）蛋白是一类非选择性阳离子通道，在整个心血管系统中广泛表达，作为Ca2+/Na+通透性通道和/或信号平台参与各种生理和病理生理机制。TRPCs与原发性高血压、心脏肥大和内皮功能障碍有关。尽管这些病症直接或间接与动脉粥样硬化病变的发展相关，但TRPCs在动脉粥样硬化发病机制中的潜在作用仍未得到探索。我们实验室最近的研究表明，TRPC3在与单核细胞募集到冠状动脉内皮相关的炎症信号传导中是必需的，这首次提示了TRPC家族成员在动脉粥样硬化发生中的潜在病理生理相关性。这就引出了一个问题，即我们是否可以将TRPCs视为动脉粥样硬化诊断、预后和/或治疗的潜在靶点。在这里，我们回顾了一些关于TRPCs和心血管病理学的现有知识，并在与动脉粥样硬化发生相关的细胞/分子过程的背景下进行讨论。讨论并对比了TRPCs作为动脉粥样硬化潜在靶点的潜在局限性和优势。
