Khara Lovedeep, Silverman Adam, Bethel Colin, D'Cruz Cyril, Sun Xinlai
Department of Surgery, Newark Beth Israel Medical Center, Saint Barnabas Health Care System, Newark, NJ 07112, USA.
J Pediatr Hematol Oncol. 2010 Apr;32(3):e118-21. doi: 10.1097/MPH.0b013e3181c97c57.
Differentiated thyroid carcinoma is a rare malignancy in children. It represents 0.4% to 3.0% of all childhood malignancies, with greater than 70% of cases presenting between the ages of 11 to 17 years and is exceptionally rare in children under 5 years of age. The most common type of differentiated thyroid carcinoma in children is papillary thyroid carcinoma, most of which are believed to be related to radiation exposure and only approximately 5% of cases have a family history of papillary thyroid cancer. In this report, we present a papillary thyroid carcinoma in a 3-year-old American boy with a family history of thyroid cancer and no known history of radiation exposure. A literature review with discussion on the management and treatment of pediatric papillary thyroid carcinoma follows.
分化型甲状腺癌在儿童中是一种罕见的恶性肿瘤。它占所有儿童恶性肿瘤的0.4%至3.0%，超过70%的病例出现在11至17岁之间，在5岁以下儿童中极为罕见。儿童分化型甲状腺癌最常见的类型是乳头状甲状腺癌，其中大多数被认为与辐射暴露有关，只有约5%的病例有乳头状甲状腺癌家族史。在本报告中，我们介绍了一名3岁美国男孩患乳头状甲状腺癌的病例，该男孩有甲状腺癌家族史且无已知辐射暴露史。随后是一篇关于儿童乳头状甲状腺癌管理和治疗的文献综述及讨论。
