一种新的绵羊实验性股骨头坏死模型。
A new preclinical femoral head osteonecrosis model in sheep.
机构信息
Tumor Unit, Orthopaedic Surgery and Traumatology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Pg Vall d'Hebron 129-139, 08035 Barcelona, Spain.
出版信息
Arch Orthop Trauma Surg. 2011 Jan;131(1):5-9. doi: 10.1007/s00402-010-1084-5. Epub 2010 Mar 9.
INTRODUCTION
Animal models have been used as insight into the pathogenesis of osteonecrosis, even though most have failed to reproduce all stages of human disease, limiting progression in experimental treatment modalities. A new surgically induced animal model of femoral head osteonecrosis in sheep is presented.
METHOD
Osteonecrosis was achieved using an improved method of intracephalic cryogenic lesion by means of a cryoprobe and vascular ligation.
RESULTS
Histologic findings at 6 and 12 weeks showed progression to advanced stage osteonecrosis. MRI, the gold standard in diagnosis and follow-up in human osteonecrosis showed concordant results with histology.
CONCLUSION
Our model can therefore be used as a preclinical femoral head osteonecrosis model in an easily accessible animal to assess biological treatments with MRI.
简介
动物模型已被用于深入了解骨坏死的发病机制，尽管大多数模型未能复制人类疾病的所有阶段，从而限制了实验治疗方法的进展。本文提出了一种新的绵羊股骨头坏死的手术诱导动物模型。
方法
采用冷冻探针和血管结扎的方法，通过颅内低温损伤实现骨坏死。
结果
6 周和 12 周的组织学发现显示进展为晚期骨坏死。MRI 是人类骨坏死的诊断和随访的金标准，其结果与组织学一致。
结论
因此，我们的模型可以作为一种易于获得的动物的临床前股骨头坏死模型，用于通过 MRI 评估生物治疗。
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