Department of Community Medicine and Rehabilitation, Section for Physiotherapy, Umeå University, Umeå, Sweden.
Exp Brain Res. 2010 May;203(1):21-30. doi: 10.1007/s00221-010-2203-9. Epub 2010 Mar 9.
This study investigates the cerebellar contribution to reactive grip control by examining differences between (22-48 years) subjects with focal cerebellar lesion due to ischaemic stroke (CL) and healthy subjects (HS). The subjects used a pinch grip to grasp and restrain an instrumented handle from moving when it was subject to unpredictable load forces of different rates (2, 4, 8, 32 N/s) or amplitudes (1, 2, 4 N). The hand ipsilateral to the lesion of the cerebellar subjects showed delayed and more variable response latencies, e.g., 278 +/- 162 ms for loads delivered at 2 N/s, compared to HS 180 +/- 53 ms (P = 0.005). The CL also used a higher pre-load grip force with the ipsilateral hand, 1.6 +/- 0.8 N, than the HS, 1.3 +/- 0.6 N (P = 0.017). In addition, the contralateral hand in subjects with unilateral cerebellar stroke showed a delayed onset of the grip response compared to HS. Cerebellar lesions thus impair the reactive grip control both in the ipsilateral and contralateral hand.
本研究通过检查因缺血性中风（CL）而导致局灶性小脑损伤的（22-48 岁）患者与健康受试者（HS）之间的差异，研究小脑对反应性抓握控制的贡献。当仪器手柄受到不同速率（2、4、8、32 N/s）或幅度（1、2、4 N）的不可预测负载力时，受试者使用捏合抓握来抓住并限制手柄移动。与 HS（180 +/- 53 ms）相比，小脑 CL 患者的患侧手的反应潜伏期延迟且更可变，例如在 2 N/s 时的负载下为 278 +/- 162 ms（P = 0.005）。CL 还使用了比 HS 更高的患侧手的预载握力，为 1.6 +/- 0.8 N，而 HS 为 1.3 +/- 0.6 N（P = 0.017）。此外，单侧小脑中风患者的对侧手的抓握反应起始延迟，与 HS 相比。因此，小脑损伤会损害患侧和对侧手的反应性抓握控制。
