Nowak Dennis A, Topka Helge, Timmann Dagmar, Boecker Henning, Hermsdörfer Joachim
Department of Neurology, University of Cologne and Institute of Medicine, Research Center Jülich, Jerpener Strasse 62, D-50924 Cologne, Germany.
Cerebellum. 2007;6(1):7-17. doi: 10.1080/14734220600776379.
Predictive control of grasping forces when manipulating objects in the environment is suggested to reflect internal models that capture the causal relationship between actions and their consequences. The anatomical correlate of predictive control of grasping within the central nervous system is not completely understood. One structure which has been related to the neural representation of internal models is the cerebellum. Given its stereotyped cytoarchitecture, the widespread connections with cortical and subcortical sensory-motor structures and the neural activity of cerebellar Purkinje cells during sensory-motor tasks, the cerebellum has long been considered to play a major role in the establishment and maintenance of sensory-motor representations related to voluntary movement. Such representations are necessary to predict the consequences of our own movements. Here we review theoretical concepts, electrophysiological, imaging and behavioural data suggesting the cerebellum to be the anatomical and functional correlate of internal models relevant for predictive control of grasping.
在环境中操纵物体时对抓握力进行预测控制，被认为反映了捕捉动作及其后果之间因果关系的内部模型。中枢神经系统内抓握预测控制的解剖学关联尚未完全明确。与内部模型的神经表征相关的一个结构是小脑。鉴于其刻板的细胞结构、与皮层和皮层下感觉运动结构广泛的连接以及在感觉运动任务中小脑浦肯野细胞的神经活动，长期以来小脑一直被认为在与自主运动相关的感觉运动表征的建立和维持中起主要作用。这种表征对于预测我们自身运动的后果是必要的。在此，我们综述了理论概念、电生理、成像和行为数据，这些数据表明小脑是与抓握预测控制相关的内部模型的解剖学和功能关联。
