Nanomedicine Research Centre, Department of Pharmaceutics, ISF College of Pharmacy , Moga, Punjab 142001 , India.
Artif Cells Nanomed Biotechnol. 2014 Aug;42(4):274-83. doi: 10.3109/21691401.2013.815194. Epub 2013 Jul 16.
Mucoadhesive drug delivery systems came into picture in the early 1980s and are one of the most studied novel delivery systems. Several researchers have focused on the investigations of the interfacial phenomena of mucoadhesion with the mucus. Mucoadhesion can be defined as a state in which two components, of which one is of biological origin, are held together for an extended period of time by the help of interfacial forces. A number of polymers have shown characteristics of bioadhesion and have been used in the formulation of various conventional and novel drug delivery systems. Studies demonstrated that these carriers not only increase the local therapeutic activity, but also increase the systemic availability of the drugs by increasing the residence time at the site of application. The current review is an attempt to throw some light on the basics of the mucoadhesion: the mechanism of bioadhesion and the polymers that are used in the design of the bioadhesive delivery system with their properties that affect the bioadhesion.
黏膜黏附给药系统于 20 世纪 80 年代初问世，是研究最多的新型给药系统之一。许多研究人员都专注于研究黏膜黏附与黏液的界面现象。黏膜黏附可以定义为两种成分（其中一种具有生物起源）通过界面力的帮助而保持在一起的状态，其中一种成分具有生物黏附特性，并已被用于各种常规和新型药物传递系统的配方中。研究表明，这些载体不仅可以提高局部治疗活性，而且可以通过增加药物在应用部位的停留时间来提高药物的全身利用率。本综述旨在探讨黏膜黏附的基础：生物黏附的机制以及用于设计生物黏附性传递系统的聚合物，以及影响生物黏附性的特性。
