Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854, USA.
J Am Chem Soc. 2010 Mar 31;132(12):4095-7. doi: 10.1021/ja1002857.
Energy coupling between distal DNA domains may have profound regulatory consequences for biological processes, allowing for allosteric control of nucleic acid function. Repair of oxidative lesions at or near triplet repeat domains can enhance DNA expansion events that result in debilitating disease states. We report here position, distance, and lesion-dependent energy crosstalk between pairs of lesions in a triplet repeat bulge loop and an adjacent duplex domain. We discuss the implications of such coupled communication between lesions in distal loop and duplex domains for lesion repair and DNA expansion associated with diseases.
远端 DNA 结构域之间的能量耦合可能对生物过程具有深远的调控作用，从而实现对核酸功能的变构控制。在三核苷酸重复结构域或其附近发生的氧化损伤的修复，可能会增强导致疾病状态的 DNA 扩展事件。我们在此报告在三核苷酸重复膨出环和相邻双链结构域中的一对损伤之间，依赖于位置、距离和损伤的能量串扰。我们讨论了这种在远端环和双链结构域中的损伤之间的偶联通讯对与疾病相关的损伤修复和 DNA 扩展的影响。
