Schwartz A E, Maneksha F R, Backus W W, Kanchuger M S, Young W L
Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Can J Anaesth. 1991 Mar;38(2):239-42. doi: 10.1007/BF03008154.
Nimodipine is a calcium antagonist that binds with high affinity to neuronal membranes. It is a potent cerebrovasodilator and has been demonstrated also to affect neurotransmitter synthesis and release. Because patients undergoing surgery for intracranial aneurysms are frequently receiving nimodipine, the authors determined the MAC of isoflurane in six dogs before and during three infusion doses of nimodipine (0.5, 1.0 and 2.0 micrograms.kg-1.min-1). MAC was also determined in five dogs before and during infusion of the drug vehicle (10 microliters.kg-1.min-1). Nimodipine produced a reduction in MAC from 1.47 +/- 0.33% to 1.19 +/- 0.18, 1.15 +/- 0.18 and 1.15 +/- 0.09% during infusions of nimodipine 0.5, 1.0 and 2.0 micrograms.kg-1.min-1, respectively (P less than 0.05). Infusion of drug vehicle alone produced no change in MAC (1.39 +/- 0.15%). This reduction in anaesthetic requirement by nimodipine may be due to its effect on neurotransmission. Adjustments in anaesthetic dosage may be necessary in patients receiving nimodipine.
尼莫地平是一种钙拮抗剂，它能与神经元膜高亲和力结合。它是一种强效脑血管扩张剂，并且已被证明还能影响神经递质的合成与释放。由于接受颅内动脉瘤手术的患者经常使用尼莫地平，作者测定了6只狗在输注三种剂量尼莫地平（0.5、1.0和2.0微克·千克⁻¹·分钟⁻¹）之前和期间异氟烷的最低肺泡有效浓度（MAC）。还测定了5只狗在输注药物载体（10微升·千克⁻¹·分钟⁻¹）之前和期间的MAC。在输注尼莫地平0.5、1.0和2.0微克·千克⁻¹·分钟⁻¹期间，尼莫地平分别使MAC从1.47±0.33%降至1.19±0.18%、1.15±0.18%和1.15±0.09%（P<0.05）。单独输注药物载体对MAC无影响（1.39±0.15%）。尼莫地平降低麻醉需求可能是由于其对神经传递的作用。接受尼莫地平治疗的患者可能需要调整麻醉剂量。
