钙通道拮抗剂增强小鼠全身麻醉效能的作用
Augmentation by calcium channel antagonists of general anaesthetic potency in mice.
作者信息
Dolin S J, Little H J
出版信息
Br J Pharmacol. 1986 Aug;88(4):909-14. doi: 10.1111/j.1476-5381.1986.tb16265.x.
Abstract
The effects of three kinds of calcium channel antagonists on the anaesthetic potencies of ethanol, pentobarbitone and argon were examined in mice. Ethanol and pentobarbitone anaesthetic potencies in mice were significantly increased by verapamil 10 mg kg-1, flunarizine 40 mg kg-1 and nitrendipine 100 mg kg-1. Argon anaesthetic potency was significantly increased by nitrendipine 50 mg kg-1 and 100 mg kg-1 in a dose-related fashion. Even at very high doses the calcium channel antagonists did not produce anaesthesia by themselves. At the doses used the calcium channel antagonists did not affect the blood concentrations of ethanol, 2 h, or pentobarbitone, 15 min, after anaesthetic administration.
摘要
研究了三种钙通道拮抗剂对小鼠乙醇、戊巴比妥和氩气麻醉效能的影响。维拉帕米10mg/kg、氟桂利嗪40mg/kg和尼群地平100mg/kg可显著提高小鼠乙醇和戊巴比妥的麻醉效能。尼群地平50mg/kg和100mg/kg可使氩气麻醉效能呈剂量依赖性显著提高。即使在非常高的剂量下，钙通道拮抗剂自身也不会产生麻醉作用。在所使用的剂量下，钙通道拮抗剂不影响麻醉给药后2小时乙醇或15分钟戊巴比妥的血药浓度。
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