Schwartz A E, Maneksha F R, Kanchuger M S, Sidhu U S, Poppers P J
Department of Anesthesiology, University of New York, Stony Brook.
Anesthesiology. 1989 May;70(5):764-6. doi: 10.1097/00000542-198905000-00010.
Flumazenil is a potent-specific benzodiazepine receptor antagonist that has been shown to reverse CNS depressant effects mediated by benzodiazepine agonists. These agonists are known to affect the interaction of gamma aminobutyric acid (GABA) with its receptor. Because the action of volatile anesthetic agents may be mediated by GABA, the authors determined the MAC of isoflurane in 16 dogs before and after one of three doses of intravenous flumazenil (0.15, 0.3, and 0.45 mg/kg) or the drug vehicle. The flumazenil produced a reduction in MAC from 1.39 +/- 0.15% (mean +/- SD) to 1.23 +/- 0.11% after 0.15 mg/kg (P less than 0.05), from 1.50 +/- 0.35% to 1.08 +/- 0.20% after 0.3 mg/kg (P less than 0.01), and from 1.45 +/- 0.14% to 1.09 +/- 0.08% after 0.45 mg/kg (P less than 0.01). Administration of drug vehicle produced no change in MAC. This reduction in isoflurane requirement by flumazenil may be due to its benzodiazepine receptor agonist action or its analgesic effect.
氟马西尼是一种强效特异性苯二氮䓬受体拮抗剂，已被证明可逆转苯二氮䓬激动剂介导的中枢神经系统抑制作用。已知这些激动剂会影响γ-氨基丁酸（GABA）与其受体的相互作用。由于挥发性麻醉剂的作用可能由GABA介导，因此作者测定了16只犬在静脉注射三种剂量（0.15、0.3和0.45mg/kg）的氟马西尼或药物赋形剂之一前后异氟烷的最低肺泡有效浓度（MAC）。氟马西尼在注射0.15mg/kg后使MAC从1.39±0.15%（平均值±标准差）降至1.23±0.11%（P<0.05），在注射0.3mg/kg后从1.50±0.35%降至1.08±0.20%（P<0.01），在注射0.45mg/kg后从1.45±0.14%降至1.09±0.08%（P<0.01）。注射药物赋形剂后MAC无变化。氟马西尼降低异氟烷需求量可能是由于其苯二氮䓬受体激动作用或镇痛作用。
