Fleischmajer R, Perlish J S, West W P
Arch Dermatol. 1977 Dec;113(12):1661-6.
Electron microscopy of the skin was performed in ten patients with systemic and four with localized scleroderma. The following three groups of cells were identified: (1) mature lymphocytes, T lymphoblasts, immature plasma cells, and plasma cells; (2) fibroblasts, fibrocytes, and fibroblast-like cells; and (3) macrophages, undifferentiated mesenchymal cells, and monocytes. Inthose specimens with mononuclear cell infiltrates, the most common cells were lymphocytic-types, macrophages, and fibroblasts with well developed rough endoplasmic reticulum. In the specimens at the fibrotic stage, fibroblasts and histiocytic-type cells predominated. This study suggests that cellular and humoral immunity may play a role in the pathophysiology of scleroderma.
对10例系统性硬皮病患者和4例局限性硬皮病患者的皮肤进行了电子显微镜检查。识别出以下三组细胞：（1）成熟淋巴细胞、T淋巴母细胞、未成熟浆细胞和浆细胞；（2）成纤维细胞、纤维细胞和成纤维样细胞；（3）巨噬细胞、未分化间充质细胞和单核细胞。在有单核细胞浸润的标本中，最常见的细胞是淋巴细胞类型、巨噬细胞和成纤维细胞，其粗面内质网发达。在纤维化阶段的标本中，成纤维细胞和组织细胞类型的细胞占主导。这项研究表明，细胞免疫和体液免疫可能在硬皮病的病理生理学中起作用。
