Fleischmajer R, Perlish J S, Reeves J R
Arthritis Rheum. 1977 May;20(4):975-84. doi: 10.1002/art.1780200410.
The purpose of this study was to determine the frequency, distribution, and nature of cellular infiltrates in 108 skin biopsies from patients with systemic scleroderma (SS) and localized scleroderma (LS). Cellular infiltrates, perivascular or diffuse, were noted in 49% of SS and 84% of LS patients and consisted of lymphocytes, plasma cells, and macrophages. No correlation was noted between the presence or severity of skin cellular infiltrates and serum serologic abnormalities.
本研究的目的是确定108例系统性硬化症（SS）和局限性硬化症（LS）患者皮肤活检中细胞浸润的频率、分布和性质。在49%的SS患者和84%的LS患者中发现有血管周围或弥漫性细胞浸润，浸润细胞包括淋巴细胞、浆细胞和巨噬细胞。皮肤细胞浸润的存在或严重程度与血清学异常之间未发现相关性。
