在 Au(III)催化的串联亲核取代-1,5-炔环异构化反应过程中发现显著的阴离子效应。

Remarkable anion effects uncovered in the development of a Au(III)-catalyzed tandem nucleophilic substitution-1,5-enyne cycloisomerization process.

机构信息

Department of Chemistry, University of York, Heslington, York, UK YO10 5DD.

出版信息

Chem Commun (Camb). 2010 Mar 28;46(12):2046-8. doi: 10.1039/b925919h. Epub 2010 Feb 15.

PMID:20221487

Abstract

(I(t)Pe)AuBr(2)(N-imidate) complexes, prepared in high yield by oxidative bromination, are active catalysts for 1,5-enyne cycloisomerization. An efficient tandem nucleophilic substitution-1,5-enyne cycloisomerization is promoted by these novel Au(III) precatalysts. Catalyst efficacy is affected by the imidate ligand and the silver salt used (e.g. Ag[Al(OC(CF(3))(3))(4)]).

摘要

（I(t)Pe）AuBr(2)(N-咪唑盐)配合物通过氧化溴化反应高产率制备，是 1,5-烯炔环异构化反应的活性催化剂。这些新型 Au(III)前催化剂促进了有效的亲核取代-1,5-烯炔环异构化串联反应。催化剂的功效受咪唑盐配体和使用的银盐（例如 Ag[Al(OC(CF(3))(3))(4)])的影响。