Tatusova Tatiana
National Institute of Heath, Bethesda, MD, USA.
Methods Mol Biol. 2010;609:17-44. doi: 10.1007/978-1-60327-241-4_2.
The National Center for Biotechnology Information (NCBI), as a primary public repository of genomic sequence data, collects and maintains enormous amounts of heterogeneous data. Data for genomes, genes, gene expressions, gene variation, gene families, proteins, and protein domains are integrated with the analytical, search, and retrieval resources through the NCBI Web site. Entrez, a text-based search and retrieval system, provides a fast and easy way to navigate across diverse biological databases.Customized genomic BLAST enables sequence similarity searches against a special collection of organism-specific sequence data and viewing the resulting alignments within a genomic context using NCBI's genome browser, Map Viewer.Comparative genome analysis tools lead to further understanding of evolutionary processes, quickening the pace of discovery.
美国国立生物技术信息中心(NCBI)作为基因组序列数据的主要公共储存库,收集并维护了大量的异构数据。通过NCBI网站,基因组、基因、基因表达、基因变异、基因家族、蛋白质和蛋白质结构域的数据与分析、搜索和检索资源整合在一起。Entrez是一个基于文本的搜索和检索系统,提供了一种快速便捷的方式来浏览各种生物数据库。定制的基因组BLAST能够针对特定生物体的序列数据特殊集合进行序列相似性搜索,并使用NCBI的基因组浏览器Map Viewer在基因组背景下查看结果比对。比较基因组分析工具有助于进一步理解进化过程,加快发现的步伐。