Wheeler David L, Smith-White Brian, Chetvernin Vyacheslav, Resenchuk Sergei, Dombrowski Susan M, Pechous Steven W, Tatusova Tatiana, Ostell James
National Center for Biotechnology Information, National Institutes of Health, Bethesda, Maryland 20894, USA.
Plant Physiol. 2005 Jul;138(3):1280-8. doi: 10.1104/pp.104.058842.
The National Center for Biotechnology Information (NCBI) integrates data from more than 20 biological databases through a flexible search and retrieval system called Entrez. A core Entrez database, Entrez Nucleotide, includes GenBank and is tightly linked to the NCBI Taxonomy database, the Entrez Protein database, and the scientific literature in PubMed. A suite of more specialized databases for genomes, genes, gene families, gene expression, gene variation, and protein domains dovetails with the core databases to make Entrez a powerful system for genomic research. Linked to the full range of Entrez databases is the NCBI Map Viewer, which displays aligned genetic, physical, and sequence maps for eukaryotic genomes including those of many plants. A specialized plant query page allow maps from all plant genomes covered by the Map Viewer to be searched in tandem to produce a display of aligned maps from several species. PlantBLAST searches against the sequences shown in the Map Viewer allow BLAST alignments to be viewed within a genomic context. In addition, precomputed sequence similarities, such as those for proteins offered by BLAST Link, enable fluid navigation from unannotated to annotated sequences, quickening the pace of discovery. NCBI Web pages for plants, such as Plant Genome Central, complete the system by providing centralized access to NCBI's genomic resources as well as links to organism-specific Web pages beyond NCBI.
美国国立生物技术信息中心(NCBI)通过一个名为Entrez的灵活搜索和检索系统整合了来自20多个生物数据库的数据。Entrez的一个核心数据库Entrez Nucleotide包含GenBank,并与NCBI分类数据库、Entrez蛋白质数据库以及PubMed中的科学文献紧密相连。一套针对基因组、基因、基因家族、基因表达、基因变异和蛋白质结构域的更专业的数据库与核心数据库相契合,使Entrez成为一个强大的基因组研究系统。与所有Entrez数据库相关联的是NCBI地图浏览器,它展示了真核生物基因组(包括许多植物的基因组)的比对遗传图谱、物理图谱和序列图谱。一个专门的植物查询页面允许对地图浏览器涵盖的所有植物基因组的图谱进行串联搜索,以生成多个物种的比对图谱展示。针对地图浏览器中显示的序列进行的PlantBLAST搜索可在基因组背景下查看BLAST比对结果。此外,预先计算的序列相似性,如BLAST Link提供的蛋白质序列相似性,可实现从无注释序列到有注释序列的流畅导航,加快发现速度。NCBI的植物网页,如植物基因组中心,通过提供对NCBI基因组资源的集中访问以及指向NCBI以外特定生物体网页的链接,完善了该系统。