Hasegawa I, Tani H, Takakuwa K, Goto S, Yamada K, Kanazawa K
Department of Obstetrics and Gynecology, Niigata University School of Medicine, Japan.
Fertil Steril. 1991 May;55(5):906-10. doi: 10.1016/s0015-0282(16)54297-6.
Using nonanti-human lymphocyte antigen (HLA) lymphocytotoxic antibodies derived from women with an abnormal pregnancy history including secondary recurrent abortion, a new series of serotyping was performed on lymphocytes from 37 couples (74 individuals), and the compatibility between the couples shown by the typing was investigated. The data demonstrated that both couples with primary recurrent abortion and infertile couples with repeated failure of embryo transfers after in vitro fertilization showed significantly close reaction patterns between partners than normal child-bearing couples by principal component factor analysis. It was concluded that this serotyping provides useful information on histocompatibility in the field of pregnancy immunology and that some cases of infertility because of implantation failure, as well as primary recurrent abortion, might be caused by underlying immunogenetical problems.
使用来自有异常妊娠史（包括继发性复发性流产）女性的非抗人淋巴细胞抗原（HLA）淋巴细胞毒性抗体，对37对夫妇（74人）的淋巴细胞进行了一系列新的血清分型，并研究了分型显示的夫妇间相容性。数据表明，通过主成分因子分析，原发性复发性流产夫妇以及体外受精后胚胎移植反复失败的不育夫妇，其伴侣间的反应模式比正常生育夫妇显著更接近。得出的结论是，这种血清分型为妊娠免疫学领域的组织相容性提供了有用信息，并且一些因植入失败导致的不育病例以及原发性复发性流产可能是由潜在的免疫遗传学问题引起的。
