Medical Department M (Endocrinology and Diabetes) and Medical Research Laboratories, Aarhus Sygehus NBG, Aarhus University Hospital, DK-8000 Aarhus C, Denmark.
J Cardiovasc Magn Reson. 2010 Mar 11;12(1):12. doi: 10.1186/1532-429X-12-12.
To investigate aortic dimensions in women with Turner syndrome (TS) in relation to aortic valve morphology, blood pressure, karyotype, and clinical characteristics.
A cross sectional study of 102 women with TS (mean age 37.7; 18-62 years) examined by cardiovascular magnetic resonance (CMR- successful in 95), echocardiography, and 24-hour ambulatory blood pressure. Aortic diameters were measured by CMR at 8 positions along the thoracic aorta. Twenty-four healthy females were recruited as controls. In TS, aortic dilatation was present at one or more positions in 22 (23%). Aortic diameter in women with TS and bicuspid aortic valve was significantly larger than in TS with tricuspid valves in both the ascending (32.4 +/- 6.7 vs. 26.0 +/- 4.4 mm; p < 0.001) and descending (21.4 +/- 3.5 vs. 18.8 +/- 2.4 mm; p < 0.001) aorta. Aortic diameter correlated to age (R = 0.2 - 0.5; p < 0.01), blood pressure (R = 0.4; p < 0.05), a history of coarctation (R = 0.3; p = 0.01) and bicuspid aortic valve (R = 0.2-0.5; p < 0.05). Body surface area only correlated with descending aortic diameter (R = 0.23; p = 0.024).
Aortic dilatation was present in 23% of adult TS women, where aortic valve morphology, age and blood pressure were major determinants of the aortic diameter.
研究特纳综合征（TS）女性的主动脉尺寸与主动脉瓣形态、血压、核型和临床特征的关系。
对 102 名经心血管磁共振（CMR-成功 95 例）、超声心动图和 24 小时动态血压检查的 TS 女性进行了横断面研究。CMR 在胸主动脉的 8 个位置测量主动脉直径。招募了 24 名健康女性作为对照组。在 TS 中，22 名（23%）女性在一个或多个位置存在主动脉扩张。在 TS 中，二叶式主动脉瓣的女性主动脉直径在升主动脉（32.4 +/- 6.7 对 26.0 +/- 4.4 毫米；p < 0.001）和降主动脉（21.4 +/- 3.5 对 18.8 +/- 2.4 毫米；p < 0.001）均明显大于三叶式主动脉瓣。主动脉直径与年龄（R = 0.2-0.5；p < 0.01）、血压（R = 0.4；p < 0.05）、缩窄病史（R = 0.3；p = 0.01）和二叶式主动脉瓣（R = 0.2-0.5；p < 0.05）相关。体表面积仅与降主动脉直径相关（R = 0.23；p = 0.024）。
23%的成年 TS 女性存在主动脉扩张，主动脉瓣形态、年龄和血压是主动脉直径的主要决定因素。
