Laboratory for Bio-Drugs of Ministry of Health, Provincial Laboratory for Modern Medicine and Technology of Shandong, Research Center for Medicinal Biotechnology, Shandong Academy of Medical Sciences, Jingshi Road, Shandong, PR China.
Cancer Cell Int. 2010 Mar 12;10:7. doi: 10.1186/1475-2867-10-7.
PADI4 post-translationally converts peptidylarginine to citrulline, a process called citrullination. Studies have demonstrated the high expression of PADI4 in various malignant tumour tissues. PADI4 is also expressed at high levels in the blood of patients with some malignant tumours. Thus far, citrullination of histone, cytokeratin, antithrombin and fibronectin have been confirmed to be involved in abnormal apoptosis, high coagulation, and disordered cell proliferation and differentiation, all of which are main features of malignant tumours. PADI4 is expressed in CD34+ stem cells in normal tissues, and many more CD34+ cells expressing PADI4 are present in tumour tissues. These findings suggest that PADI4 may play an important role in tumourigenesis.
PADI4 可对肽基精氨酸进行翻译后修饰，使其转变为瓜氨酸，这一过程称为瓜氨酸化。研究表明，PADI4 在多种恶性肿瘤组织中呈高表达状态。PADI4 在某些恶性肿瘤患者的血液中也呈高表达水平。迄今为止，组蛋白、细胞角蛋白、抗凝血酶和纤维连接蛋白的瓜氨酸化已被证实与异常凋亡、高凝血、细胞增殖和分化紊乱有关，这些都是恶性肿瘤的主要特征。PADI4 在正常组织中的 CD34+干细胞中表达，在肿瘤组织中存在更多表达 PADI4 的 CD34+细胞。这些发现表明 PADI4 可能在肿瘤发生中发挥重要作用。
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