Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
Phys Med Biol. 2010 Apr 7;55(7):1917-34. doi: 10.1088/0031-9155/55/7/009. Epub 2010 Mar 12.
In this paper we describe a method for quantitative photoacoustic tomography (qPAT) based on the photon radiative transfer equation (RTE) coupled with the Helmholtz photoacoustic wave equation. Considerable simulations and tissue-like phantom experiments are conducted to evaluate transport-based qPAT in comparison with diffusion-based qPAT. In these comparative simulations and experiments, we systematically examine the effects of the ratio of mu(a)/mu'(s) (absorption/reduced scattering coefficient), the anisotropy factor (g) and the imaging domain size on the transport- and diffusion-based photoacoustic image reconstruction. The results obtained show that transport-based qPAT allows for clearly more accurate recovery of the absolute absorption coefficient images of heterogeneous media over diffusion-based qPAT for all the cases examined and provides considerably improved image quality for cases where the photon diffusion approximation (DA) is invalid.
在本文中，我们描述了一种基于光子辐射传输方程（RTE）与亥姆霍兹光声波方程相结合的定量光声断层成像（qPAT）方法。进行了大量的模拟和组织样体实验，以评估基于传输的 qPAT 与基于扩散的 qPAT 的比较。在这些比较模拟和实验中，我们系统地研究了 mu(a)/mu'(s)（吸收/降低散射系数）的比值、各向异性因子（g）和成像域大小对基于传输和扩散的光声图像重建的影响。结果表明，对于所有检查的情况，基于传输的 qPAT 允许比基于扩散的 qPAT 更准确地恢复异质介质的绝对吸收系数图像，并为光子扩散近似（DA）无效的情况提供了显著提高的图像质量。
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