Institute of Pneumology at the University Witten/Herdecke, Clinic for Pneumology and Allergology, Center of Sleep Medicine and Respiratory Care, Bethanien Hospital, Solingen, Germany.
Respiration. 2010;80(2):139-45. doi: 10.1159/000295904. Epub 2010 Mar 11.
The measurement of CO(2) partial pressure (PCO(2)) is of great importance. Former systems of transcutaneous capnometry combining the measurement of oxygen partial pressure (PO(2)) and PCO(2) had their limitations due to skin irritations caused by the heating-up of the sensor and a short application time of 4 h.
To evaluate for the first time combined monitoring of transcutaneous PCO(2) (tcPCO(2)) and oxygen saturation applying a lower temperature (sensor temperature 42 degrees C) and a new sensor technology in healthy individuals during sleep.
Twenty-nine healthy individuals [12 males, age 35.2 +/- 17.0 years, body height: 170.2 +/- 12.0 cm (mean +/- SD), weight: 76.3 +/- 15.8 kg, body mass index 26.5 +/- 5.4] were monitored for more than 6 h at night with the TOSCA 500 instrument (Radiometer, Basel, Switzerland). tcPCO(2) was continuously monitored and its correlation with selective measured capillary PCO(2) values (PcapCO(2)) was monitored at 0.00 and 4.00 h.
At 0.00 h, PcapCO(2) was 37.1 +/- 5.1 mm Hg and tcPCO(2) was 43.4 +/- 6.6 mm Hg (p < 0.001). At 4.00 h, PcapCO(2) was 37.0 +/- 5.6 mm Hg and tcPCO(2) was 43.5 +/- 5.4 mm Hg (p < 0.001). PcapCO(2) and tcPCO(2) were positively and significantly correlated (0.00 h: r = 0.5, p < 0.02 and 4.00 h: r = 0.72 and p < 0.001) at both time points. In the course of the night, there was no significant drift in the tcPCO(2) values.
The investigated system enables stable measurement of tcPCO(2) without relevant drift in healthy individuals and does not require recalibration. tcPCO(2) is highly suitable as a measure of PcapCO(2) because the two parameters are highly correlated and there is no inconvenience to the patient.
二氧化碳分压（PCO2）的测量非常重要。以前的经皮二氧化碳测量系统（transcutaneous capnometry）结合了氧分压（PO2）和 PCO2 的测量，但由于传感器加热引起的皮肤刺激以及应用时间只有 4 小时，存在一定局限性。
首次评估在健康个体睡眠期间应用较低温度（传感器温度 42°C）和新型传感器技术进行经皮 PCO2（tcPCO2）和氧饱和度的联合监测。
29 名健康个体[12 名男性，年龄 35.2±17.0 岁，身高 170.2±12.0cm（均值±SD），体重 76.3±15.8kg，体重指数 26.5±5.4]使用 TOSCA 500 仪器（丹麦雷度米特公司）进行了超过 6 小时的夜间监测。tcPCO2 连续监测，并在 0.00 和 4.00 小时监测其与选择性测量的毛细血管 PCO2 值（PcapCO2）的相关性。
0.00 小时时，PcapCO2 为 37.1±5.1mmHg，tcPCO2 为 43.4±6.6mmHg（p<0.001）。4.00 小时时，PcapCO2 为 37.0±5.6mmHg，tcPCO2 为 43.5±5.4mmHg（p<0.001）。PcapCO2 和 tcPCO2 在两个时间点均呈正相关（0.00 小时：r=0.5，p<0.02；4.00 小时：r=0.72，p<0.001）。在夜间过程中，tcPCO2 值无明显漂移。
该系统在健康个体中可稳定测量 tcPCO2，无明显漂移，无需重新校准。tcPCO2 非常适合作为 PcapCO2 的测量指标，因为这两个参数高度相关，且患者无不适。
