Diestelhorst M, Aspacher F, Konen W, Krieglstein G K
University Eye Hospital Cologne, FRG.
Int Ophthalmol. 1991 Mar;15(2):69-73. doi: 10.1007/BF01046423.
Preoperative and postoperative anterior chamber fluorophotometry were performed after intravenous administration of fluorescein sodium in patients undergoing extracapsular extraction and posterior chamber lens implantation. The topical application of aqueous flurbiprofen sodium 0.03% solution before and after surgery significantly decreased the surgery mediated disturbance of the blood aqueous barrier as compared to vehicle application (placebo controlled). In contrast to similar studies, cortical steroids were not given topically or systemically to either group of patients during the study. The present fluorophotometric results correlate well with slitlamp biomicroscopy of postoperative inflammation. The data of this study indicate that flurbiprofen ophthalmic solution is effective in protecting the blood aqueous barrier (BAB) in human eyes during cataract surgery and IOL implantation.
对接受囊外摘除术和后房型人工晶状体植入术的患者静脉注射荧光素钠后，进行术前和术后前房荧光光度测定。与使用赋形剂（安慰剂对照）相比，手术前后局部应用0.03%氟比洛芬钠水溶液可显著降低手术介导的血-房水屏障干扰。与类似研究不同的是，在研究期间两组患者均未局部或全身给予皮质类固醇。目前的荧光光度测定结果与术后炎症的裂隙灯生物显微镜检查结果密切相关。本研究数据表明，氟比洛芬滴眼液在白内障手术和人工晶状体植入术中对保护人眼血-房水屏障（BAB）有效。
