Cillino S, Casanova F, Cucco F, Ponte F
University Eye Clinic of Palermo, Italy.
J Cataract Refract Surg. 1993 Sep;19(5):622-5. doi: 10.1016/s0886-3350(13)80013-2.
Recent clinical studies indicate that flurbiprofen, a cyclooxygenase inhibitor, prevents miosis and breakdown of the blood-aqueous barrier during cataract surgery. Yet based on clinical and experimental data, some researchers do not agree that flurbiprofen prevents miosis. We conducted a double-blind clinical study of the effects of topical 0.03% flurbiprofen sodium on intraoperative pupillary diameter and iris fluorescein leakage after extracapsular cataract surgery. In the first phase of the study, 120 patients who had extracapsular cataract extraction with posterior chamber intraocular lens implantation were randomly assigned to receive preoperative topical flurbiprofen or a placebo, with or without intraoperative epinephrine, in addition to the standard regimen. In the second phase, 60 of the 120 patients continued the topical flurbiprofen or placebo for one month postoperatively. Iris fluorescein angiography was performed at the end of the first and the fourth weeks. The results indicate that flurbiprofen was significantly more effective (P < .0001) in maintaining mydriasis during surgery than the placebo. This action was enhanced by intraoperative epinephrine. Flurbiprofen also significantly reduced (P < .001) postoperative iris fluorescein leakage.
近期临床研究表明，环氧化酶抑制剂氟比洛芬可防止白内障手术期间瞳孔缩小和血-房水屏障的破坏。然而，基于临床和实验数据，一些研究人员不同意氟比洛芬可防止瞳孔缩小这一观点。我们进行了一项双盲临床研究，以探讨局部应用0.03%氟比洛芬钠对囊外白内障摘除术后术中瞳孔直径和虹膜荧光素渗漏的影响。在研究的第一阶段，120例行囊外白内障摘除联合后房型人工晶状体植入术的患者被随机分配，除标准治疗方案外，术前局部应用氟比洛芬或安慰剂，并给予或不给予术中肾上腺素。在第二阶段，120例患者中的60例在术后继续局部应用氟比洛芬或安慰剂1个月。在第一周和第四周结束时进行虹膜荧光素血管造影。结果表明，在手术期间维持瞳孔散大方面，氟比洛芬比安慰剂显著更有效（P < .0001）。术中使用肾上腺素可增强这一作用。氟比洛芬还显著减少了术后虹膜荧光素渗漏（P < .001）。
