Integrated Department of Immunology, University of Colorado Denver and National Jewish Health, 80206, USA.
Nat Rev Immunol. 2010 Apr;10(4):272-7. doi: 10.1038/nri2743. Epub 2010 Mar 12.
Following stimulation through their T cell receptor, invariant natural killer T (iNKT) cells function as innate effector cells by rapidly releasing large amounts of effector cytokines and chemokines and therefore have an important role in modulating the ensuing immune response. iNKT cells recognize, and are activated by, diverse glycolipid antigens, many of which are found in microorganisms. However, iNKT cells also show some reactivity to 'self'. Here, I outline our current understanding of iNKT cell autoreactivity and propose that several self lipids are probably involved in the positive selection and autoreactivity of iNKT cells.
在其 T 细胞受体受到刺激后，不变自然杀伤 T(iNKT)细胞通过快速释放大量效应细胞因子和趋化因子而作为先天效应细胞发挥作用，因此在调节随后的免疫反应中具有重要作用。iNKT 细胞识别并被多种糖脂抗原激活，其中许多存在于微生物中。然而，iNKT 细胞也对“自身”表现出一定的反应性。在这里，我概述了我们目前对 iNKT 细胞自身反应性的理解，并提出几种自身脂质可能参与了 iNKT 细胞的阳性选择和自身反应性。
